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製品番号: HY-129514

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Bayer 9017

Bayer 9017 is an insecticide with plasma cholinesterase inhibitory activity and toxicity. Bayer 9017 inhibits plasma cholinesterase activity in chicks. Bayer 9017 prevents the colonization of Lucilia sericata larvae, kills first-instar Lucilia sericata larvae, and provides myiasis protection for sheep, with seasonal variations in its protective performance. Bayer 9017 is applicable to research related to myiasis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 52-60-8
分子式: C₁₃H₂₁O₃PS₂
分子量:320.40

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Bayer 9017 構造式

CAS 番号: 52-60-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

Cholinesterase (ChE) アイソフォーム固有の製品をすべて表示 :

AChE
BChE

体内実験

Bayer 9017 (200-800 ppm; oral administration; daily dosing; for 3 weeks) exhibits acute oral toxicity in young White Leghorn roosters, with an LD₅₀ of 17.9 mg/kg. In contrast, subacute toxicity induced via feed administration causes dose-dependent mortality, plasma cholinesterase inhibition and initial growth retardation, while the growth of surviving individuals gradually recovers over time^[1].
Bayer 9017 (250-400 ppm; medicated bath immersion; single dose) provides sheep with complete protection against myiasis for at least 10-20 weeks and partial protection for 14-24 weeks^[2].
Bayer 9017 (400 ppm; administered via a single dipping treatment) provides 16-26 weeks of protection against artificial myiasis in Romney sheep, with a residual duration of 18-30 weeks in wool^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Single Comb White Leghorn cockerels (10- to 12-day-old)^[1]
Dosage:

17.9 mg/kg (acute study); 200-800 ppm (subacute study)
Administration:

p.o.; single dose (acute study); daily; 3 weeks (subacute study)
Result:

Determined an LD₅₀ of 17.9 mg/kg, with all deaths emerging within 8 hours after exposure.
Triggered full lethality by week 2 at 800 ppm, accompanied by 5% week 1 mortality, 94% plasma cholinesterase suppression and reduced week 1 weight-gain ratio of 0.77.
Produced cumulative 45% mortality by week 3 at 400 ppm, including 0% week 1 death and 25% week 2 death; brought about 92% week 1 and 100% week 2 plasma cholinesterase inhibition, alongside lowered week 1 and week 2 weight-gain ratios of 1.01 and 1.12.
Led to zero mortality within 3 weeks at 200 ppm, induced 83% week 1 and 86% week 2 plasma cholinesterase inhibition, and generated decreased week 1 weight-gain ratio of 1.30 and week 2 ratio of 1.36; surviving subjects exhibited growth exceeding control levels after early exposure stage.

化学情報

CAS 番号 52-60-8
分子量 320.40
分子式 C₁₃H₂₁O₃PS₂
SMILES

S=P(OC=1C=C(C(SC)=C(C1)C)C)(OCC)OCC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Sherman M, et al. Further studies on the acute and subacute toxicity of insecticides to chicks. Toxicology and Applied Pharmacology, 1967, 11(1): 49-67.

[2]. Millar E S. Fly-strike control in sheep: An evaluation of further new compounds. New Zealand Veterinary Journal, 1966, 14(12): 215-216.

[3]. Heath AC. New insecticides: as sheep dips against Lucilia sericata. N Z Vet J. 1971 Mar;19(3):45-6. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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生物活性
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化学情報
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Bayer 9017

Parasite アイソフォーム固有の製品をすべて表示

Cholinesterase (ChE) アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bayer 9017 関連分類

HY-129514 関連分類