Bicyclomycin
Bicyclomycin is an antibiotic. Bicyclomycin exhibits selective antibacterial activity against Gram-negative bacteria such as Escherichia coli and Klebsiella spp., with no cross-resistance. Bicyclomycin is applicable to the research of infectious diseases.
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- CAS 番号: 38129-37-2
- 分子式: C12H18N2O7
- 分子量:302.28
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Bicyclomycin (6-25 μg/mL; 2 h) induces dose-dependent morphological changes (cell elongation, spheroplast formation) in actively growing cells of E. coli strain 15 THU and the highly sensitive E. coli strain ATCC 27166[1].
Bicyclomycin (25-100 μg/mL; 0-60 min) inhibits RNA and protein synthesis in proliferating E. coli 15 THU cells, but does not affect their DNA or lipid synthesis[1].
Bicyclomycin (100 μg/mL, over 0-45 min) exerts a stronger inhibitory effect on bound lipoprotein synthesis (inhibition rate of approximately 95%) than on free lipoprotein (inhibition rate of approximately 60%) and envelope protein synthesis (inhibition rate of approximately 50%) in histidine-starved E. coli 15 THU cells, with no effect on cytoplasmic protein synthesis[1].
Bicyclomycin exhibits selective moderate antibacterial activity against specific Gram-negative bacteria (Escherichia coli NIHJ JC-2, Klebsiella pneumoniae ST-101, Salmonella typhosa T-287, Shigella flexneri 1a-2 W-A), with an MIC of 25 mcg/mL; it shows only weak activity against Sarcina lutea PCI-100 (MIC 250 mcg/mL); and it has no activity against other tested Gram-positive bacteria, Gram-negative bacteria, mycobacteria, fungi, or yeasts[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 38129-37-2
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性状 Solid
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分子量 302.28
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分子式 C12H18N2O7
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Color White to off-white
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SMILES
OC[C@](C)(O)[C@@H]([C@]12C(N[C@](C(N1)=O)(C(CCO2)=C)O)=O)O
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Structure Classification
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Initial Source
sterptomyces cinnamoneus
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (278 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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