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製品番号: HY-164702

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BL-B01D1

Name: BL-B01D1
Brand: MedChemExpress
SKU: HY-164702
Price: 1450.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(別名: Izalontamab Brengitecan)

カスタマーレビュー

Based on 1 Customer Validation

BL-B01D1 (Izalontamab Brengitecan) is a bispecific antibody-drug conjugate (ADC) targeting EGFR and HER3, formed by conjugating the EGFR/HER3 bispecific antibody Izalontamab (HY-P99676) to a novel TOP-I inhibitor payload Deruxtecan 2-hydroxypropanamide (HY-153891) via a cleavable linker (Mc-Gly-Gly-Phe-Gly). BL-B01D1 binds to EGFR and HER3 on the surface of tumor cells, mediates endocytosis and releases the payload, inhibits topoisomerase I, blocks DNA replication and RNA synthesis, and disrupts DNA structure. BL-B01D1 induces cell cycle S-phase arrest, apoptosis, antibody-dependent cell-mediated cytotoxicity, and tumor cell death. BL-B01D1 can be used for cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 96.38%
分子量:205830.00

保管条件:

-80°C, protect from light

BL-B01D1 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

One-stop CDMO Service

One-Stop Platform：From Independent R&D to Pilot-Scale Production

生物活性
- 製品説明
- IC₅₀ & Target
- 体内実験
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]^[2]^[3]^[4]^[5]

Topoisomerase I

EGFR

HER3

EGFR アイソフォーム固有の製品をすべて表示 :

Topoisomerase アイソフォーム固有の製品をすべて表示 :

体内実験

BL-B01D1 (Izalontamab Brengitecan) exhibits superior in vivo antitumor activity compared to single-target EGFR or HER3 antibody-drug conjugates in cancer-patient-derived tumor xenograft models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

性状 Liquid
分子量 205830.00
Color Colorless to light yellow
SMILES

[BL-B01D1]
別名

Izalontamab Brengitecan
輸送条件

Shipping with dry ice.
保管条件

-80°C, protect from light

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wan W, et al. Abstract 2642: BL‑B01D1, a novel EGFR×HER3‑targeting ADC, demonstrates robust anti‑tumor efficacy in preclinical evaluation. Cancer Research. 2023 Apr 4;83(7_Supplement):2642.

[2]. Liu C, et al. A bispecific antibody-drug conjugate targeting EGFR and HER3 in metastatic esophageal squamous cell carcinoma: a phase 1b trial. Nat Med. 2025 Oct;31(10):3485-3491.

[3]. Ma Y, et al. BL-B01D1, a first-in-class EGFR-HER3 bispecific antibody-drug conjugate, in patients with locally advanced or metastatic solid tumours: a first-in-human, open-label, multicentre, phase 1 study. Lancet Oncol. 2024 Jul;25(7):901-911. [Content Brief]

[4]. Bian X, et al. Efficacy and Safety of BL-B01D1 in Patients With Locally Advanced or Metastatic Urothelial Carcinoma: A Phase II Clinical Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2025 Nov 10;43(32):3505-3515.

[5]. Zhang L, et al. BL‑B01D1, a first‑in‑class EGFR×HER3 bispecific antibody‑drug conjugate (ADC), in patients with locally advanced or metastatic solid tumor: Results from a first‑in‑human phase 1 study. Journal of Clinical Oncology. 2023 Jun;41(16_suppl):3001.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体内実験
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献

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BL-B01D1

EGFR アイソフォーム固有の製品をすべて表示

Topoisomerase アイソフォーム固有の製品をすべて表示