BMY 28674
BMY 28674 (6-Hydroxybuspirone) is the active metabolite of the anxiolytic buspirone (HY-B1115A) and is metabolized by CYP3A4.4. BMY 28674 binds to the serotonin (5-HT) receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe (EC50s are 4 and 1 μM, respectively) and is an antagonist of dopamine D2, D3, and D4 receptors (IC50s are 3.1, 4.9, and 0.85 μM, respectively). BMY 28674 also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 expressing human transporters in S2 proximal tubule cells in a concentration-dependent manner.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 125481-61-0
- 分子式: C21H31N5O3
- 分子量:401.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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5-HT1A Receptor |
Rat 5-HT1A Receptor 4 μM (EC50) |
D2 Receptor 3.1 μM (IC50) |
D3 Receptor 4.9 μM (IC50) |
D4 Receptor 0.85 μM (IC50) |
Rat 5-HT1A Receptor 1 μM (EC50) |
化学情報
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CAS 番号 125481-61-0
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分子量 401.50
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分子式 C21H31N5O3
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SMILES
O=C(N(CCCCN1CCN(C2=NC=CC=N2)CC1)C(C3)=O)C(O)C43CCCC4
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別名
6-Hydroxybuspirone; 6'-Hydroxybuspirone; BMS 528215
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BMY 28674 関連分類
HY-100057 関連分類
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