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Brodalumab

(別名: AMG 827; KHK4827)
4 Cited Publications
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Based on 4 publication(s) in Google Scholar

Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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  • 純度: 99.18%
  • CAS 番号: 1174395-19-7
  • 分子量:144.06 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Brodalumab
  • Experimental Validation Results for Brodalumab
  • Experimental Validation Results for Brodalumab
  • Experimental Validation Results for Brodalumab
  • Experimental Validation Results for Brodalumab
  • Experimental Validation Results for Brodalumab
  • Experimental Validation Results for Brodalumab
  • Experimental Validation Results for Brodalumab
  • Brodalumab Chemical Structure
    Brodalumab 構造式
CAS 番号: 1174395-19-7
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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MedChemExpress（MCE）の使用を引用している文献 Brodalumab

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Customer Validation & Images
In Vivo Efficacy StudyHistological Imaging/StainingWBIF
  • In Vivo Efficacy Study
  • Histological Imaging/Staining
  • WB
  • IF
  • Histological Imaging/Staining

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Assay Types
  • 1/16

    Human IgG2 kappa

  • 1/16

    Immobilized IL-17RA Protein, Human can bind Brodalumab. The EC50 for this effect is 7.1 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 K562 cells with Brodalumab (HY-P9925, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Brodalumab purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Feb;12(6):e2310169. [Abstract]

    Customer Validation
     Representative skin ultrasound images in corresponding groups. Quantification of dermal thickness is shown at the bottom. Anti-IL-17RA mAb (Brodalumab; 200 μg; s.c.; once weekly on days 1, 8, and 15) reduced dermal thickness in the skin of BLM-SSc mice compared with isotype control IgG.

  • 1/16

    Brodalumab purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Feb;12(6):e2310169. [Abstract]

    Customer Validation
     Brodalumab (anti-IL-17RA mAb; 200 μg; s.c.; once weekly on days 1, 8, and 15). (i) Representative HE (left) and Masson (right) staining of skin corresponding groups. (ii) Quantification of dermal thickness. (iii) Hydroxyproline contents of skin samples.

  • 1/16

    Brodalumab purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Feb;12(6):e2310169. [Abstract]

    Customer Validation
     Representative WB images of indicated proteins in skin samples of each group. Brodalumab (anti-IL-17RA mAb; 200 μg; s.c.; once weekly on days 1, 8, and 15) reduced α-SMA and Col1A1 expression and downregulated NF-κB/MAPK pathway-related phosphorylated proteins in the skin of BLM-SSc mice.

  • 1/16

    Brodalumab purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Feb;12(6):e2310169. [Abstract]

    Customer Validation
     Representative immunofluorescence images of skin stained with indicated antibodies in corresponding groups. Brodalumab (anti‐IL‐17RA mAb; 200 μg; s.c.; once weekly on days 1, 8, and 15) reduced α-SMA and Col1A1 fluorescence signals in the skin of BLM-SSc mice.

  • 1/16

    Brodalumab purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2025 Dec 3;73(48):30761-30776. [Abstract]

    Customer Validation
     Images of H&E staining. Brodalumab (0.5 mg/kg; i.p.; once daily for 7 days; mice) restored colonic crypt and goblet cell structures and reduced inflammatory cell infiltration.

  • Brodalumab Chemical Structure
    1/16
  • Brodalumab
  • Immobilized IL-17RA Protein, Human can bind Brodalumab. The EC50 for this effect is 7.1 ng/mL.
  • Flow cytometric analysis of 1X106 K562 cells with Brodalumab (HY-P9925, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).