Caplacizumab (His Tag)
Based on 2 publication(s) in Google Scholar
Caplacizumab (His Tag) is a humanized anti-von Willebrand factor (vWF) nanobody. Caplacizumab (His Tag) inhibits the binding of vWF with platelet glycoprotein (GP) Ibα. Caplacizumab (His Tag) inhibits the vWF-mediated platelet adhesion and prevents further microthrombi formation. Caplacizumab (His Tag) can be used for the research of thrombotic thrombocytopenic purpura (TTP).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.83%
- CAS 番号: 915810-67-2
- 分子量:29 kDa
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保管条件:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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化学情報
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 Caplacizumab (His Tag)
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Customer Validation & Images
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Histological Imaging/Staining
生物活性
製品説明
Isotype
VH-VH
Species Reactivity
Human
IC50 & Target
VWF
体外実験
Caplacizumab (His Tag) inhibits the binding of VWF with platelet glycoprotein (GP) Ibα in blood specimens[2].
Caplacizumab (His Tag) (0.8 μg/mL) can completely inhibit platelet adhesion to the collagen surface at high shear rates (>1500 s-1)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
Caplacizumab (His Tag) (at plasma levels between 0.3-0.5 μg/mL, i.v. bolus) shows a strong antithrombotic effect in a modified Folts model in baboons[4].
Caplacizumab (His Tag) (5 mg/kg total dose with intravenous and subcutaneous injection; intravenous injection first and subcutaneous injections follow) prevents middle cerebral artery thrombosis in a guinea pig model of middle cerebral artery thrombosis, and reduces brain damage without inducing hemorrhage[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Guinea pig (Dunkin-Hartley, male, 350-400 g) model of middle cerebral artery thrombosis[5]
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Dosage:5 mg/kg total dose (0.4 mg/kg intravenously + 1.6 mg/kg subcutaneously at time 0 followed by 3 mg/kg subcutaneously 6 h later)
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Administration:Intravenous injection first and subcutaneous injections follow
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Result:Prevented thrombosis when administered immediately after and 15 min after complete occlusion of the middle cerebral artery.
Reduced brain damage area and did not increase intracerebral hemorrhage.
Reduced microvascular thrombosis in the ischemic brain tissue.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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VH-VH
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Human VWF-A1 (1260–1554aa)-Fc can bind Caplacizumab. The EC50 for this effect is 7.442 ng/mL.
化学情報
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CAS 番号 915810-67-2
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性状 Liquid
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分子量 29 kDa
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Color Colorless to light yellow
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SMILES
[Caplacizumab (His Tag)]
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別名
ALX-0681; ALX-0081
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Caplacizumab (His Tag) purchased from MedChemExpress. Usage Cited in: Adv Ophthalmol Pract Res. 2025 Nov 21.
Representative images of the retinal flat-mounts stained with IB4 from OIR + Vehicle group, and OIR + ALX-0681 (Caplacizumab (His Tag), 1 μg/mL, diluted to a final volume of 1 μL before intravitreal injection into the right eye of P12 mice) group after OIR induction at P17. Neovascular and avascular areas are indicated by the white dots and white area, respectively.
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純度とドキュメンテーション
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データシート (264 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Maëlle le Besnerais, et al. Caplacizumab: a change in the paradigm of thrombotic thrombocytopenic purpura treatment. Expert Opin Biol Ther. 2019 Nov;19(11):1127-1134. [Content Brief]
[3]. Callewaert F, et al. Evaluation of efficacy and safety of the anti-VWF Nanobody ALX-0681 in a preclinical baboon model of acquired thrombotic thrombocytopenic purpura. Blood. 2012 Oct 25;120(17):3603-10. [Content Brief]
[4]. Ulrichts H, et al. Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs. Blood. 2011 Jul 21;118(3):757-65. [Content Brief]
[5]. Momi S, et al. Reperfusion of cerebral artery thrombosis by the GPIb-VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs. Blood. 2013 Jun 20;121(25):5088-97. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Caplacizumab (His Tag) 関連分類
HY-P99227 関連分類
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