製品番号: HY-115449

Chromeceptin

(別名: 94G6)

2 Cited Publications

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR.

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純度: 99.80%
CAS 番号: 331859-86-0
分子式: C₁₉H₁₆F₃N₃O
分子量:359.35

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Chromeceptin 構造式

CAS 番号: 331859-86-0

容量

価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Akt アイソフォーム固有の製品をすべて表示 :

mTOR アイソフォーム固有の製品をすべて表示 :

体外実験

Chromeceptin (94G6) (5 μM) inhibits IGF2 expression in Hep3B-derived TS cells in a time-dependent manner^[1].
Chromeceptin decreases the Phosphorylation levels of protein kinase B (AKT, Ser463) and rapamycin (mTOR, Ser 2481 and Ser 2448) in TS cells^[1].
Chromeceptin represses the phosphorylation at ser371 in mTOR effectors ribosomal protein S6 kinase (p70S6K)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 331859-86-0
性状 Solid
分子量 359.35
分子式 C₁₉H₁₆F₃N₃O
Color White to light yellow
SMILES

N#CC1=C(N)OC2=CC(N(C)C)=CC=C2C1C3=CC=CC(C(F)(F)F)=C3
別名

94G6
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Int J Biol Sci

Mechanical stretch-induced IGF2 overexpression in epidermal keratinocytes promotes hypertrophic scar formation through the IGF1R/p-c-Jun axis. [Abstract]

2025 Jan 1;21(1):109-127. PMID: 39744430
Aquaculture

2026 Jan 4;615:743618.

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (278.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7828 mL

13.9140 mL

27.8280 mL

5 mM

0.5566 mL

2.7828 mL

5.5656 mL

10 mM

0.2783 mL

1.3914 mL

2.7828 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 10 mg/mL (27.83 mM); Suspended solution; Need ultrasonic

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Seol HS, et al. Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma. Sci Rep. 2020 Dec 8;10(1):21412. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7828 mL	13.9140 mL	27.8280 mL	69.5701 mL
	5 mM	0.5566 mL	2.7828 mL	5.5656 mL	13.9140 mL
	10 mM	0.2783 mL	1.3914 mL	2.7828 mL	6.9570 mL
	15 mM	0.1855 mL	0.9276 mL	1.8552 mL	4.6380 mL
	20 mM	0.1391 mL	0.6957 mL	1.3914 mL	3.4785 mL
	25 mM	0.1113 mL	0.5566 mL	1.1131 mL	2.7828 mL
	30 mM	0.0928 mL	0.4638 mL	0.9276 mL	2.3190 mL
	40 mM	0.0696 mL	0.3479 mL	0.6957 mL	1.7393 mL
	50 mM	0.0557 mL	0.2783 mL	0.5566 mL	1.3914 mL
	60 mM	0.0464 mL	0.2319 mL	0.4638 mL	1.1595 mL
	80 mM	0.0348 mL	0.1739 mL	0.3479 mL	0.8696 mL
	100 mM	0.0278 mL	0.1391 mL	0.2783 mL	0.6957 mL

Keywords

Chromeceptin

2 Cited Publications

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Chromeceptin

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MedChemExpress（MCE）の使用を引用している文献 Chromeceptin

Akt アイソフォーム固有の製品をすべて表示

mTOR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (2)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Chromeceptin 関連分類

HY-115449 関連分類