Cinanserin
Based on 1 publication(s) in Google Scholar
Cinanserin (SQ 10643) is a potent and selective 5-HT2 antagonist with Ki values of 41, 3500 nM for 5-HT2, 5-HT1, respectively. Cinanserin also is a SARS-CoV 3CLpro inhibitor with an KD value of 49.4, 18.2 µM for SARS-CoV 3CLpro, HCoV-229E 3CLpro, respectively. Cinanserin reduces systemic burn edema levels.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1166-34-3
- 分子式: C20H24N2OS
- 分子量:340.48
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Cinanserin
More5-HT Receptor アイソフォーム固有の製品をすべて表示
More
生物活性
|
5-HT2 Receptor 41 nM (Ki) |
5-HT1 Receptor 3500 nM (Ki) |
SARS-CoV 3CLpro 49.4 μM (Kd) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
31 μM
Compound: 8
|
Cytotoxicity against african green monkey Vero E6 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against african green monkey Vero E6 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay
|
[PMID: 23231439] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Wistar rats (250 g) underwent thermal injury[1]
-
Dosage:5 mg/kg
-
Administration:Intravenous injection; for 2 hours
-
Result:Significantly reduced systemic burn edema to shamburn levels, leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin.
化学情報
-
CAS 番号 1166-34-3
-
分子量 340.48
-
分子式 C20H24N2OS
-
SMILES
O=C(NC1=CC=CC=C1SCCCN(C)C)/C=C/C2=CC=CC=C2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Sci Rep
Hepatitis C virus NS3/4A inhibitors and other drug-like compounds as covalent binders of SARS-CoV-2 main protease. [Abstract]2022 Jul 16;12(1):12197. PMID: 35842458
純度とドキュメンテーション
参考文献
[1]. Hernekamp JF, et al. Cinanserin reduces plasma extravasation after burn plasma transfer in rats. Burns. 2013 Sep;39(6):1226-33. [Content Brief]
[2]. Chen L, et al. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J Virol. 2005 Jun;79(11):7095-103. [Content Brief]
[3]. Leysen, J. E., et al. Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors. Life Sciences, 1981, 28(9), 1015-1022. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cinanserin 関連分類
HY-133828 関連分類
Powered by Bioz