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製品番号: HY-149769

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CP-506

CP-506 (compound 26) is an anticancer compound and a substrate for nitroreductase and CYP oxidoreductases. CP-506 has anticancer activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 2227303-52-6
分子式: C₁₉H₂₉BrN₄O₈S₂
分子量:585.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

CP-506 構造式

CAS 番号: 2227303-52-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

CP-506 (compound 26) is an anticancer compound and a substrate for nitroreductase and CYP oxidoreductases. CP-506 has anticancer activity^[1].

IC₅₀ & Target

Nitroreductase, CYP oxidoreductase^[1]

Cytochrome P450 アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	1.2 μM Compound: 26; CP-506	Antiproliferative activity against human HCT-116 cells overexpressing cytochrome P450 oxidoreductase assessed as inhibition of cell growth incubated for 4 hrs under anoxic condition and measured after 5 days regrowth under aerobic condition Antiproliferative activity against human HCT-116 cells overexpressing cytochrome P450 oxidoreductase assessed as inhibition of cell growth incubated for 4 hrs under anoxic condition and measured after 5 days regrowth under aerobic condition	[PMID: 37974941]
HCT-116	IC₅₀	112 μM Compound: 26; CP-506	Antiproliferative activity against human HCT-116 cells overexpressing cytochrome P450 oxidoreductase assessed as inhibition of cell growth incubated for 4 hrs under aerobic condition and measured after 5 days regrowth under aerobic condition Antiproliferative activity against human HCT-116 cells overexpressing cytochrome P450 oxidoreductase assessed as inhibition of cell growth incubated for 4 hrs under aerobic condition and measured after 5 days regrowth under aerobic condition	[PMID: 37974941]
HCT-116	IC₅₀	14 μM Compound: 26; CP-506	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 4 hrs under anoxic condition and measured after 5 days regrowth under aerobic condition Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 4 hrs under anoxic condition and measured after 5 days regrowth under aerobic condition	[PMID: 37974941]
HCT-116	IC₅₀	288 μM Compound: 26; CP-506	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 4 hrs under aerobic condition and measured after 5 days regrowth under aerobic condition Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 4 hrs under aerobic condition and measured after 5 days regrowth under aerobic condition	[PMID: 37974941]
SiHa	IC₅₀	22 μM Compound: 26; CP-506	Antiproliferative activity against human SiHa cells assessed as inhibition of cell growth incubated for 4 hrs under anoxic condition and measured after 5 days regrowth under aerobic condition Antiproliferative activity against human SiHa cells assessed as inhibition of cell growth incubated for 4 hrs under anoxic condition and measured after 5 days regrowth under aerobic condition	[PMID: 37974941]
SiHa	IC₅₀	459 μM Compound: 26; CP-506	Antiproliferative activity against human SiHa cells assessed as inhibition of cell growth incubated for 4 hrs under aerobic condition and measured after 5 days regrowth under aerobic condition Antiproliferative activity against human SiHa cells assessed as inhibition of cell growth incubated for 4 hrs under aerobic condition and measured after 5 days regrowth under aerobic condition	[PMID: 37974941]

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 2227303-52-6
分子量 585.49
分子式 C₁₉H₂₉BrN₄O₈S₂
SMILES

CS(=O)(OCCN(CCBr)C1=CC(C(N2CCN(CC)CC2)=O)=C([N+]([O-])=O)C=C1S(=O)(C)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ashoorzadeh A et al. Design and Biological Evaluation of Piperazine-Bearing Nitrobenzamide Hypoxia/GDEPT Prodrugs: The Discovery of CP-506. ACS Med Chem Lett. 2023 Oct 5;14(11):1517-1523. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献

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CP-506

Cytochrome P450 アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

CP-506 関連分類

HY-149769 関連分類