Cycotiamine
Cycotiamine is an S-acylated thiamine derivative with antiplasmodial activity. Cycotiamine inhibits the proliferation of Plasmodium falciparum and Plasmodium knowlesi. Cycotiamine can be used in malaria-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 6092-18-8
- 分子式: C13H16N4O3S
- 分子量:308.36
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Cycotiamine (compound 12) exhibits IC50 values of 123 μM, 127 μM, and 176 μM against P. falciparum under extracellular thiamine concentrations of 0 μM, 2.97 μM, and 297 μM, respectively. The IC50 of cycotiamine against P. knowlesi exceeds 1000 μM, showing weaker anti-parasitic activity than other thiamine analogs in the same series. The IC50 of cycotiamine against human fibroblast HFF cells exceeds 1000 μM, with no obvious cytotoxicity[1].
Cycotiamine (serial dilution; 96 h) inhibits the proliferation of both Plasmodium falciparum strain 3D7-GFP and PfTPK-GFP-overexpressing Plasmodium to the same extent, indicating that its anti-Plasmodium effect is independent of thiamine pyrophosphokinase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 6092-18-8
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分子量 308.36
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分子式 C13H16N4O3S
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SMILES
O=CN(CC1=CN=C(C)N=C1N)/C(C)=C2SC(OCC/2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cycotiamine 関連分類
HY-W742094 関連分類
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