Decapeptide-12
Based on 1 Customer Validation
Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.68%
- CAS 番号: 137665-91-9
- 分子式: KS3WY3
- 分子量:1395.52
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Decapeptide-12 (P4, 0.01-10 mΜ) dose-dependently inhibits mushroom tyrosinase with an IC50 value of 40 μM, and inhibits human tyrosinase by 25-35% at 100 μM[1].
Decapeptide-12 (100 μM, 7 days) leads to 43% reduction in melanin content in melanocytes with no effect on cell proliferation[1].
Decapeptide-12 (peptide P4, 0-400 μM) inhibits the monophenolase reaction with an IC50 value of 123 μM[2].
Decapeptide-12 interact with tyrosinase with a Kd value of 61.1 μM[2].
Decapeptide-12 (100 μM, 72 h) increases transcription of SIRT1, SIRT3, SIRT6, and SIRT7 with reduced cytotoxicity in human neonatal keratinocyte progenitors[3].
Decapeptide-12 (0-1 mM, 72 h) reduces Phytohemagglutinin (PHA)-stimulated PBMC cells proliferation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Phytohemagglutinin (PHA)-stimulated PBMC cells
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Concentration:0, 0.025, 0.05, 0.1, 0.3, 1 mM
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Incubation Time:72 h
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Result:Reduced cell proliferation by 28% at 0.05 mM and 54% at 0.1 mM.
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Cell Line:Human neonatal keratinocyte progenitors
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Concentration:3, 10, 30, 50, 100, 300, 500, 1000 μM
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Incubation Time:72 h
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Result:Increased transcription of SIRT1 by 141% relative to untreated cells, increased SIRT3, SIRT6 and SIRT7 by 121%, 147% and 95%, respectively.
化学情報
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CAS 番号 137665-91-9
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性状 Solid
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分子量 1395.52
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分子式 KS3WY3
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Color White to off-white
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シーケンスの短縮
YRSRKYSSWY
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
H2O : ≥ 100 mg/mL (71.66 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Anan Abu Ubeid, et al. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J Invest Dermatol. 2009 Sep;129(9):2242-9. [Content Brief]
[2]. Akihito Ochiai, et al. New tyrosinase inhibitory decapeptide: Molecular insights into the role of tyrosine residues. J Biosci Bioeng. 2016 Jun;121(6):607-613. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.7166 mL | 3.5829 mL | 7.1658 mL | 17.9145 mL |
| 5 mM | 0.1433 mL | 0.7166 mL | 1.4332 mL | 3.5829 mL | |
| 10 mM | 0.0717 mL | 0.3583 mL | 0.7166 mL | 1.7914 mL | |
| 15 mM | 0.0478 mL | 0.2389 mL | 0.4777 mL | 1.1943 mL | |
| 20 mM | 0.0358 mL | 0.1791 mL | 0.3583 mL | 0.8957 mL | |
| 25 mM | 0.0287 mL | 0.1433 mL | 0.2866 mL | 0.7166 mL | |
| 30 mM | 0.0239 mL | 0.1194 mL | 0.2389 mL | 0.5971 mL | |
| 40 mM | 0.0179 mL | 0.0896 mL | 0.1791 mL | 0.4479 mL | |
| 50 mM | 0.0143 mL | 0.0717 mL | 0.1433 mL | 0.3583 mL | |
| 60 mM | 0.0119 mL | 0.0597 mL | 0.1194 mL | 0.2986 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Decapeptide-12 関連分類
HY-P0096 関連分類
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