Dehydrocrenatine
Dehydrocrenatidine, a β-carboline alkaloid that can be isolated from Picrasma quassioides. Dehydrocrenatidine induces cell apoptosis by activates ERK and JNK. Dehydrocrenatidine inhibits invasion and migration of cancer cells, it also suppresses neuronal excitability to exert analgesic effects.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 26585-13-7
- 分子式: C14H12N2O
- 分子量:224.26
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
4.77 μg/mL
Compound: 50
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Antiproliferative activity against human A2780 cells
Antiproliferative activity against human A2780 cells
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[PMID: 34332400] |
| SK-OV-3 | IC50 |
15.72 μg/mL
Compound: 50
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Antiproliferative activity against human SK-OV-3 cells
Antiproliferative activity against human SK-OV-3 cells
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[PMID: 34332400] |
化学情報
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CAS 番号 26585-13-7
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分子量 224.26
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分子式 C14H12N2O
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SMILES
COC1=CN=C(C=C)C(N2)=C1C3=C2C=CC=C3
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Ho HY, et al. Apoptotic effects of dehydrocrenatidine via JNK and ERK pathway regulation in oral squamous cell carcinoma. Biomed Pharmacother. 2021 May;137:111362. [Content Brief]
[2]. Hsieh MC, et al. Dehydrocrenatidine extracted from Picrasma quassioidesinduces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways. Oncol Rep. 2021 Aug;46(2):166. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Dehydrocrenatine 関連分類
HY-N3711 関連分類
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