Dehydromiltirone
Based on 1 Customer Validation
Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.11%
- CAS 番号: 116064-77-8
- 分子式: C19H20O2
- 分子量:280.36
-
保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Dehydromiltirone (100 μg/mL; for 24 h) inhibits p38 and NF-κB signaling in Kupffer cells[1].
Dehydromiltirone inhibits the expression of osteoclast-associated genes, including NFATc1, CTSK, c-Fos, Acp5, and MMP9; and the phosphorylation of P38, ERK, and JNK of the MAPK signaling pathway; and the degradation of IκB-α of NF-κB signaling pathway. Dehydromiltirone exhibits an anti-osteoclastogenesis effect by reducing the expression of related genes, ultimately inhibiting bone resorption in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Kupffer cells
-
Concentration:100 μg/mL
-
Incubation Time:For 24 h
-
Result:Significantly decreased p38 and p-p38 levels, NF-κBp65, IκB, and c-fos protein levels.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Rat model of acute liver injury[1]
-
Dosage:50 mg/kg, 100 mg/kg, and 200 mg/kg
-
Administration:p.o.; daily; for five consecutive days
-
Result:Protected liver from CCl4-induced damage.
化学情報
-
CAS 番号 116064-77-8
-
性状 Solid
-
分子量 280.36
-
分子式 C19H20O2
-
Color Pink to red
-
SMILES
O=C1C(C(C)C)=CC2=C(C3=C(C=C2)C(C)(C)CC=C3)C1=O
-
別名
1,2-Didehydromiltirone
-
Structure Classification
-
Initial Source
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
純度とドキュメンテーション
-
データシート (276 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Shuqiang Yue, et al. Salvia miltiorrhiza compounds protect the liver from acute injury by regulation of p38 and NFκB signaling in Kupffer cells. Pharm Biol. 2014 Oct;52(10):1278-85. [Content Brief]
[2]. Wei Deng, et al. Dehydromiltirone inhibits osteoclast differentiation in RAW264.7 and bone marrow macrophages by modulating MAPK and NF-κB activity. Front Pharmacol. 2022 Sep 21;13:1015693. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Dehydromiltirone 関連分類
HY-122961 関連分類
Powered by Bioz