Dideoxy-amanitin
Dideoxy-amanitin (compound 2), an α-Amanitin (HY-19610) derivative, is a potent and selective RNA polymerase II allosteric inhibitor with an IC50 value of 74.2 nM.
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- CAS 番号: 58255-46-2
- 分子式: C39H54N10O12S
- 分子量:886.97
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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RNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
1.3 μM
Compound: Dideoxy amanitin
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Cytotoxicity against chinese hamster CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against chinese hamster CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 35696491] |
Dideoxy-amanitin (compound 2; 0.078-20 μM; 24 h) has cell cytotoxicity in CHO (Chinese hamster ovary) cells with an IC50 value of 0.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CHO (Chinese hamster ovary) cells
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Concentration:0.078-20 μM
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Incubation Time:24 hours
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Result:Decreased cell proliferation in a dose-depengdent manner.
化学情報
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CAS 番号 58255-46-2
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分子量 886.97
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分子式 C39H54N10O12S
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SMILES
C[C@H]([C@H](NC([C@@H]1C[C@@H](O)CN1C([C@@H]2CC(N)=O)=O)=O)C(N[C@@H](CC3=C(SC[C@H](N4)C(N2)=O)NC5=C3C=CC=C5)C(NCC(N[C@H](C(NCC4=O)=O)[C@@H](C)CC)=O)=O)=O)[C@@H](O)CO
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Dideoxy-amanitin 関連分類
HY-148231 関連分類
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