DOI hydrochloride
Based on 1 publication(s) in Google Scholar
DOI hydrochloride is a serotonin 5-HT2A/2C receptor agonist with Ki values of 0.7 nM, 2.4 nM and 20 nM for h5-HT2A, h5-HT2C and h5-HT2B receptors, respectively. DOI hydrochloride can across the blood-brain barrier. DOI hydrochloride increases head twitches in mice.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.6%
- CAS 番号: 42203-78-1
- 分子式: C11H17ClINO2
- 分子量:357.62
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 DOI hydrochloride
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In Vivo Efficacy Study
5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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5-HT2B Receptor |
5-HT2C Receptor |
Human 5-HT2A Receptor 0.7 nM (Ki) |
Human 5-HT2C Receptor 2.4 nM (Ki) |
human 5-HT2B Receptor 20 nM (Ki) |
DOI hydrochloride (10 μM; for 45 min) causes a massive increase in adhesion with 99% of the cells staying adherent compared to only 42% of untreated Hu2AAB1 cells[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
DOI (0.35-0.7 mmol/kg; sc) significantly increases waking and light sleep and reduces slow wave sleep, rapid-eye-movement (REM) sleep, and the number of REM periods in Male Wistar rats weighing 350-400 g[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 42203-78-1
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性状 Solid
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分子量 357.62
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分子式 C11H17ClINO2
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Color White to light yellow
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SMILES
NC(C)CC1=CC(OC)=C(I)C=C1OC.[H]Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biomed Pharmacother
Pharmacological effects of MT-1207 in bilateral renal artery stenosis hypertension and its hypotensive targets validation. [Abstract]2024 Aug 5:178:117234. PMID: 39106710
DOI hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Aug 5:178:117234. [Abstract]
MT blocks DOI hydrochloride (3 mg/kg, iv, single dose)-induced BP elevation, as shown by systolic BP changes before and after DOI administration under pre-treatment of Vehicle or MT.
溶剤 & 溶解度
H2O : 25 mg/mL (69.91 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. D L Nelson, et al. Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jan;359(1):1-6. [Content Brief]
[2]. S L Shepheard, et al. Investigation of the effects of IVth ventricular administration of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), on autonomic outflow in the anaesthetized cat. Br J Pharmacol. 1991 Oct;104(2):367-72. [Content Brief]
[3]. Mark J Benvenga, et al. Metabotropic Glutamate 2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice. Front Pharmacol. 2018 Mar 15;9:208. [Content Brief]
[4]. Jaime M Monti, et al. Effects of the serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat. Eur J Pharmacol. 2006 Dec 28;553(1-3):163-70. [Content Brief]
[5]. Joe Anand Kumar John Jayakumar, et al. Serotonin 2A (5-HT 2A) receptor affects cell-matrix adhesion and the formation and maintenance of stress fibers in HEK293 cells. Sci Rep. 2020 Dec 10;10(1):21675. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.7963 mL | 13.9813 mL | 27.9626 mL | 69.9066 mL |
| 5 mM | 0.5593 mL | 2.7963 mL | 5.5925 mL | 13.9813 mL | |
| 10 mM | 0.2796 mL | 1.3981 mL | 2.7963 mL | 6.9907 mL | |
| 15 mM | 0.1864 mL | 0.9321 mL | 1.8642 mL | 4.6604 mL | |
| 20 mM | 0.1398 mL | 0.6991 mL | 1.3981 mL | 3.4953 mL | |
| 25 mM | 0.1119 mL | 0.5593 mL | 1.1185 mL | 2.7963 mL | |
| 30 mM | 0.0932 mL | 0.4660 mL | 0.9321 mL | 2.3302 mL | |
| 40 mM | 0.0699 mL | 0.3495 mL | 0.6991 mL | 1.7477 mL | |
| 50 mM | 0.0559 mL | 0.2796 mL | 0.5593 mL | 1.3981 mL | |
| 60 mM | 0.0466 mL | 0.2330 mL | 0.4660 mL | 1.1651 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
DOI hydrochloride 関連分類
HY-103124 関連分類
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