E(c(RGDfK))2
Based on 1 Customer Validation
E (c (RGDfK)) 2 is a αvβ3 integrin ligand and tumor-targeting agent. E (c (RGDfK)) 2 binds to αvβ3 integrin, mediates receptor-mediated endocytosis of conjugated payloads, and inhibits integrin-dependent cell adhesion to fibrinogen. E (c (RGDfK)) 2 inhibits the proliferation of cancer cells and endothelial cells. E (c (RGDfK)) 2 preferentially accumulates in orthotopic mouse breast tumors and human ovarian cancer xenograft tumors. E (c (RGDfK)) 2 can be used in research related to glioblastoma, lung cancer, breast adenocarcinoma and ovarian cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.82%
- CAS 番号: 250612-47-6
- 分子式: C59H87N19O16
- 分子量:1318.44
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
E(c(RGDfK))2 (72 hr) weakly inhibits the viability of U87-MG human glioblastoma cells and human umbilical vein endothelial cells, with IC50 values of 2500 nM and 400 nM, respectively[1].
E(c(RGDfK))2 (50 μM; 30 min pre-incubation) reduces the adhesion of human umbilical vein endothelial cells to fibrinogen by approximately 35%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
E(c(RGDfK))2 (54.5 mg/kg; i.v.; 3 total doses on days 10, 17, 24) shows minimal antitumor efficacy against OVCAR-3 xenografts, with an optimum T/C of 80% at day 27[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 250612-47-6
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性状 Solid
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分子量 1318.44
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分子式 C59H87N19O16
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Color White to off-white
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配列
Glu[cyclo(Arg-Gly-Asp-{d-Phe}-Lys)]-cyclo(Arg-Gly-Asp-{d-Phe}-Lys)
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シーケンスの短縮
E[cyclo(RGD-{d-Phe}-K)]-cyclo(RGD-{d-Phe}-K)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (75.85 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (252 KB)
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- Français - FR (252 KB)
- Deutsch - DE (252 KB)
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- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7585 mL | 3.7924 mL | 7.5847 mL | 18.9618 mL |
| 5 mM | 0.1517 mL | 0.7585 mL | 1.5169 mL | 3.7924 mL | |
| 10 mM | 0.0758 mL | 0.3792 mL | 0.7585 mL | 1.8962 mL | |
| 15 mM | 0.0506 mL | 0.2528 mL | 0.5056 mL | 1.2641 mL | |
| 20 mM | 0.0379 mL | 0.1896 mL | 0.3792 mL | 0.9481 mL | |
| 25 mM | 0.0303 mL | 0.1517 mL | 0.3034 mL | 0.7585 mL | |
| 30 mM | 0.0253 mL | 0.1264 mL | 0.2528 mL | 0.6321 mL | |
| 40 mM | 0.0190 mL | 0.0948 mL | 0.1896 mL | 0.4740 mL | |
| 50 mM | 0.0152 mL | 0.0758 mL | 0.1517 mL | 0.3792 mL | |
| 60 mM | 0.0126 mL | 0.0632 mL | 0.1264 mL | 0.3160 mL |
E(c(RGDfK))2 関連分類
HY-P5098 関連分類
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