SLC41A1 - solute carrier family 41 member 1 Gene

Also Known as MgtE; NPHPL2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 254428

About SLC41A1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,789,095-205,813,198 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in heart (RPKM 55.1), testis (RPKM 27.0) and 20 other tissues.

Summary

Enables magnesium ion transmembrane transporter activity and magnesium:sodium antiporter activity. Involved in cellular magnesium ion homeostasis; cellular response to magnesium ion; and magnesium ion transmembrane transport. Located in basolateral plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

SLC41A1 Products (1)

mRNA	Protein	Name
NM_173854.6	NP_776253.3	solute carrier family 41 member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables magnesium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	18367447	GOA
enables magnesium:sodium antiporter activity	IMP IMP: Inferred from mutant phenotype	22031603	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables transmembrane transporter activity	IDA IDA: Inferred from direct assay	23661805	GOA
enables transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	22031603	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in cellular response to magnesium ion	IGI IGI: Inferred from genetic interaction	21696366	GOA
involved in intracellular magnesium ion homeostasis	IMP IMP: Inferred from mutant phenotype	22031603	GOA
involved in magnesium ion transmembrane transport	IDA IDA: Inferred from direct assay	18367447	GOA
involved in magnesium ion transport	IDA IDA: Inferred from direct assay	18367447	GOA
involved in magnesium ion transport	IMP IMP: Inferred from mutant phenotype	22031603	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	23661805	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18367447	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	18367447	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC41A1 Protein Structure

MgtE

0
100
200
300
400
513 a.a.

Protein Preferred Names	Protein Names
solute carrier family 41 member 1	solute carrier family 41 (magnesium transporter), member 1

SLC41A1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SLC41A1	Q8IVJ1	ELOVL7	Homo sapiens	A1L3X0	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	ELOVL7	Homo sapiens	A1L3X0	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	TMEM248	Homo sapiens	Q9NWD8	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	TMEM248	Homo sapiens	Q9NWD8	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	TMEM248	Homo sapiens	Q9NWD8	Validated Y2H	32296183
Intra	SLC41A1	Q8IVJ1	CLN5	Homo sapiens	O75503	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	CLN5	Homo sapiens	O75503	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	SLC41A1	Q8IVJ1	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	AVPR2	Homo sapiens	P30518	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	AVPR2	Homo sapiens	P30518	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	SLC13A4	Homo sapiens	Q9UKG4	Validated Y2H	32296183
Intra	SLC41A1	Q8IVJ1	SLC13A4	Homo sapiens	Q9UKG4	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	SLC13A4	Homo sapiens	Q9UKG4	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	GPR61	Homo sapiens	Q9BZJ8	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	GPR61	Homo sapiens	Q9BZJ8	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	GPR61	Homo sapiens	Q9BZJ8	Validated Y2H	32296183
Intra	SLC41A1	Q8IVJ1	TAAR9	Homo sapiens	Q96RI9	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	TAAR9	Homo sapiens	Q96RI9	Validated Y2H	32296183
Intra	SLC41A1	Q8IVJ1	TAAR9	Homo sapiens	Q96RI9	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	SLC41A1	Q8IVJ1	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	SLC41A1	Q8IVJ1	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	SLC41A1	Q8IVJ1	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	FFAR3	Homo sapiens	O14843	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	FFAR3	Homo sapiens	O14843	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	GPR101	Homo sapiens	Q96P66	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	GPR101	Homo sapiens	Q96P66	Validated Y2H	32296183
Intra	SLC41A1	Q8IVJ1	GPR101	Homo sapiens	Q96P66	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	TRHR	Homo sapiens	P34981	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	TRHR	Homo sapiens	P34981	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	SYPL2	Homo sapiens	Q5VXT5-2	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	SYPL2	Homo sapiens	Q5VXT5-2	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	TBXA2R	Homo sapiens	Q0VAB0	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	TBXA2R	Homo sapiens	Q0VAB0	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	SLC41A1	Q8IVJ1	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	SCAMP2	Homo sapiens	O15127	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	SCAMP2	Homo sapiens	O15127	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	SYNDIG1	Homo sapiens	Q9H7V2	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	SYNDIG1	Homo sapiens	Q9H7V2	Validated Y2H	32296183
Intra	SLC41A1	Q8IVJ1	SYNDIG1	Homo sapiens	Q9H7V2	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	SLC41A1	Q8IVJ1	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	GJA5	Homo sapiens	P36382	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	GJA5	Homo sapiens	P36382	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	SLC41A1	Q8IVJ1	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	SLC41A1	Q8IVJ1	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	SLC41A1	Q8IVJ1	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Nephronophthisis-Like Nephropathy 2	NPHPL2
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	XMEN X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia Cid Due To Magt1 Deficiency Combined Immunodeficiency Due To Magt1 Deficiency X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Hypomagnesemia 1, Intestinal	Intestinal Hypomagnesemia 1 HOMG1 Hypomagnesemia With Secondary Hypocalcemia Hsh Hypomagnesemic Tetany Intestinal Hypomagnesemia With Secondary Hypocalcemia Homg Hypomagnesemia Caused By Selective Magnesium Malabsorption Hypomagnesemia Intestinal Type 1 Primary Hypomagnesemia With Secondary Hypocalcemia Phsh Hypomagnesemia, Intestinal, With Secondary Hypocalcemia Familial Primary Hypomagnesemia With Hypocalcuria Hypomagnesemia 1 Hypomagnesmic Tetany
Urofacial Syndrome 1	Urofacial Syndrome Ochoa Syndrome Hydronephrosis With Peculiar Facial Expression Ufs Inverted Smile And Occult Neuropathic Bladder Partial Facial Palsy With Urinary Abnormalities UFS1 Urofacial Ochoa'S Syndrome Urofacial Syndrome Type 1 Facial Palsy, Partial, With Urinary Abnormalities Hydronephrosis-Inverted Smile Inverted Smile-Neurogenic Bladder Hydronephrosis-Inverted Smile Syndrome Inverted Smile-Neurogenic Bladder Syndrome Partial Facial Palsy Partial With Urinary Abnormalities Urologic Diseases
Primary Hypomagnesemia	Familial Primary Hypomagnesemia Homg Primary Familial Hypomagnesemia Genetic Primary Hypomagnesemia Hypomagnesemia 1, Intestinal
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS13246	SLC41A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	SLC41A1	VGNC	VGNC:34873
Canis familiaris	SLC41A1	VGNC	VGNC:46412
Macaca mulatta	SLC41A1	VGNC	VGNC:77515
Rattus norvegicus	SLC41A1	RGD	RGD:1311397
Mus musculus	SLC41A1	MGD	MGI:2444823
Felis catus	SLC41A1	VGNC	VGNC:65368
Others	SLC41A1	NCBI