BAD - BCL2 associated agonist of cell death Gene
Also Known as BBC2; BCL2L8
生物種: Homo sapiens
About BAD
This gene has 7 transcripts (splice variants) and 79 orthologues. Ubiquitous expression in colon (RPKM 20.0), fat (RPKM 18.4) and 25 other tissues.
Summary
The protein encoded by this gene is a member of the Bcl-2 Family. Bcl-2 Family members are known to be regulators of programmed cell death. This protein positively regulates cell Apoptosis by forming heterodimers with Bcl-xL (B-cell lymphoma-extra large) and Bcl-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein Kinases AKT and MAP kinase, as well as protein phosphatase Calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019]
BAD Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_004322.3 | NP_004313.1 | bcl2-associated agonist of cell death |
| NM_032989.3 | NP_116784.1 | bcl2-associated agonist of cell death |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables cysteine-type endopeptidase activator activity involved in apoptotic process |
IDA
IDA: Inferred from direct assay
|
18402937 | GOA |
| enables lipid binding |
IDA
IDA: Inferred from direct assay
|
19667065 | GOA |
| enables phospholipid binding |
IMP
IMP: Inferred from mutant phenotype
|
21081150 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9388232 | GOA |
| enables protein kinase binding |
IPI
IPI: Inferred from physical interaction
|
17270021 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| part of BAD-BCL-2 complex |
IPI
IPI: Inferred from physical interaction
|
9463381 | GOA |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
20700721 | GOA |
| located in mitochondrial outer membrane |
IDA
IDA: Inferred from direct assay
|
20700721 | GOA |
BAD Protein Structure
Bcl-2_BAD: Pro-apoptotic Bcl-2 protein, BAD (1 - 168)
- 0
- 100
- 168 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
bcl2-associated agonist of cell death |
|
BAD Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
BAD | Q92934 | CAPN1 | Homo sapiens | P07384 | 32814053 | |
|
Intra
|
BAD | Q92934 | CAPN1 | Homo sapiens | P07384 | 32814053 | |
|
Intra
|
BAD | Q92934 | CAPN1 | Homo sapiens | P07384 | 32814053 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817-1 | 20603619 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817-1 | 15131699 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817-1 | 9388232 | |
|
Intra
|
BAD | Q92934 | YWHAH | Homo sapiens | Q04917 | 31980649 | |
|
Intra
|
BAD | Q92934 | YWHAZ | Homo sapiens | P63104 | 31980649 | |
|
Intra
|
BAD | Q92934 | YWHAZ | Homo sapiens | P63104 | 19667065 | |
|
Intra
|
BAD | Q92934 | YWHAZ | Homo sapiens | P63104 | 23397142 | |
|
Intra
|
BAD | Q92934 | YWHAZ | Homo sapiens | P63104 | 21988832 | |
|
Intra
|
BAD | Q92934 | YWHAE | Homo sapiens | P62258 | 33961781 | |
|
Intra
|
BAD | Q92934 | YWHAE | Homo sapiens | P62258 | 20936779 | |
|
Intra
|
BAD | Q92934 | YWHAE | Homo sapiens | P62258 | 31980649 | |
|
Intra
|
BAD | Q92934 | YWHAE | Homo sapiens | P62258 | 36931259 | |
|
Intra
|
BAD | Q92934 | YWHAB | Homo sapiens | P31946 | 21900206 | |
|
Intra
|
BAD | Q92934 | YWHAB | Homo sapiens | P31946 | 31980649 | |
|
Intra
|
BAD | Q92934 | YWHAG | Homo sapiens | P61981 | 31980649 | |
|
Intra
|
BAD | Q92934 | YWHAG | Homo sapiens | P61981 | 20936779 | |
|
Intra
|
BAD | Q92934 | YWHAQ | Homo sapiens | P27348 | 31980649 | |
|
Intra
|
BAD | Q92934 | YWHAQ | Homo sapiens | P27348 | 21988832 | |
|
Intra
|
BAD | Q92934 | SFN | Homo sapiens | P31947 | 31980649 | |
|
Intra
|
BAD | Q92934 | SFN | Homo sapiens | P31947 | 20179209 | |
|
Intra
|
BAD | Q92934 | SFN | Homo sapiens | P31947 | 16189514 | |
|
Intra
|
BAD | Q92934 | SFN | Homo sapiens | P31947 | 33961781 | |
|
Intra
|
BAD | Q92934 | BCL2L11 | Homo sapiens | O43521 | 19427863 | |
|
Intra
|
BAD | Q92934 | BCL2L2 | Homo sapiens | Q92843 | 15694340 | |
|
Cross
|
BAD | Q92934 | OPG035 | vaccinia virus | P17361 | 17485524 | |
|
Intra
|
BAD | Q92934 | BCL2 | Homo sapiens | P10415 | 17446862 | |
|
Intra
|
BAD | Q92934 | BCL2 | Homo sapiens | P10415 | 9388232 | |
|
Intra
|
BAD | Q92934 | BCL2 | Homo sapiens | P10415 | 9463381 | |
|
Intra
|
BAD | Q92934 | ACTN2 | Homo sapiens | P35609 | 32296183 | |
|
Intra
|
BAD | Q92934 | ACTN2 | Homo sapiens | P35609 | 32296183 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817 | 31980649 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817 | 31515488 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817 | 31467278 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817 | 25416956 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817 | 31467278 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817 | 29997244 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817 | 32814053 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817 | 37398436 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817 | 31467278 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817 | 19427857 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817 | 29997244 | |
|
Intra
|
BAD | Q92934 | BCL2L1 | Homo sapiens | Q07817 | 25241761 | |
|
Intra
|
BAD | Q92934 | BNIP3L | Homo sapiens | O60238 | 9973195 | |
|
Intra
|
BAD | Q92934 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
BAD | Q92934 | KRT31 | Homo sapiens | Q15323 | 32296183 |
BAD 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P80025 | Bad Antibody (YA593) | WB, ICC/IF, IHC-P, FC, IP | Human |
| HY-P83354 | Phospho-Bad (Ser112) Antibody (YA3099) | WB, IP | Human, Mouse, Rat |
| HY-P86533 | Bad Antibody (YA6225) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
関連疾患
| Diseases | Alias | |
|---|---|---|
| B-Cell Lymphoma |
|
|
| Transient Cerebral Ischemia |
|
|
| Endometrial Cancer |
|
|
| Lymphoma |
|
|
| Colorectal Cancer |
|
|
| Lung Cancer |
|
|
| Melanoma |
|
|
| Prostate Cancer |
|
|
| Breast Cancer |
|
|
| Acute Promyelocytic Leukemia |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Felis catus | BAD | VGNC | VGNC:102738 |
| Bos taurus | BAD | VGNC | VGNC:26404 |
| Mus musculus | BAD | MGD | MGI:1096330 |
| Canis familiaris | BAD | VGNC | VGNC:38362 |
| Rattus norvegicus | BAD | RGD | RGD:620103 |
| Macaca mulatta | BAD | VGNC | VGNC:70218 |
| Others | BAD | NCBI |