LITAF - lipopolysaccharide induced TNF factor Gene

Also Known as PIG7; SIMPLE; TP53I7

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 9516

About LITAF

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:11,547,722-11,640,317 (from NCBI)

This gene has 19 transcripts (splice variants), 198 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in appendix (RPKM 52.8), thyroid (RPKM 42.1) and 25 other tissues.

Summary

Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and Other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]

LITAF Products (3)

mRNA	Protein	Name
NM_001136472.2	NP_001129944.1	lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 1
NM_001136473.1	NP_001129945.1	lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 2
NM_004862.4	NP_004853.2	lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	21217782	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12655064	GOA
enables WW domain binding	IPI IPI: Inferred from physical interaction	15064722	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	27927196	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15064722	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	27582497	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21217782	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15064722	GOA
located in Golgi apparatus	IMP IMP: Inferred from mutant phenotype	16118794	GOA
located in cytoplasmic side of early endosome membrane	IDA IDA: Inferred from direct assay	27582497	GOA
located in cytoplasmic side of late endosome membrane	IDA IDA: Inferred from direct assay	27582497	GOA
located in cytoplasmic side of lysosomal membrane	IDA IDA: Inferred from direct assay	27582497	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	27582497	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	11274176	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	16118794	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
lipopolysaccharide-induced tumor necrosis factor-alpha factor	LPS-induced TNF-alpha factor

LITAF Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	LITAF	Q99732	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25910212
Intra	LITAF	Q99732	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	LITAF	Q99732	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	LITAF	Q99732	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25910212
Intra	LITAF	Q99732	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Bait-Prey Pool	25910212
Intra	LITAF	Q99732	KCNIP4	Homo sapiens	Q6PIL6	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	KCNIP4	Homo sapiens	Q6PIL6	Y2H Array	32296183
Intra	LITAF	Q99732	EPN1	Homo sapiens	Q9Y6I3-3	Y2H Array	32296183
Intra	LITAF	Q99732	EPN1	Homo sapiens	Q9Y6I3-3	Validated Y2H	32296183
Intra	LITAF	Q99732	EPN1	Homo sapiens	Q9Y6I3-3	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	LITAF	Q99732	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	LITAF	Q99732	GGA3	Homo sapiens	Q9NZ52-2	Validated Y2H	32296183
Intra	LITAF	Q99732	GGA3	Homo sapiens	Q9NZ52-2	Y2H Array	32296183
Intra	LITAF	Q99732	GGA3	Homo sapiens	Q9NZ52-2	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	TOM1	Homo sapiens	O60784-2	Y2H Array	32296183
Intra	LITAF	Q99732	TOM1	Homo sapiens	O60784-2	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	EPN2	Homo sapiens	O95208-2	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	EPN2	Homo sapiens	O95208-2	Y2H Array	32296183
Intra	LITAF	Q99732	EPN3	Homo sapiens	I6L9I8	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	EPN3	Homo sapiens	I6L9I8	Y2H Array	32296183
Intra	LITAF	Q99732	REEP6	Homo sapiens	Q96HR9-2	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	REEP6	Homo sapiens	Q96HR9-2	Y2H Array	32296183
Intra	LITAF	Q99732	CDCA4	Homo sapiens	Q9BXL8	Y2H Pooling	32814053
Intra	LITAF	Q99732	CDCA4	Homo sapiens	Q9BXL8	Validated Y2H	32814053
Intra	LITAF	Q99732	CDCA4	Homo sapiens	Q9BXL8	Y2H Array	32814053
Intra	LITAF	Q99732	KCNIP1	Homo sapiens	Q9NZI2-2	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	KCNIP1	Homo sapiens	Q9NZI2-2	Validated Y2H	32296183
Intra	LITAF	Q99732	KCNIP1	Homo sapiens	Q9NZI2-2	Y2H Array	32296183
Intra	LITAF	Q99732	TNIP3	Homo sapiens	Q96KP6	Y2H Array	32296183
Intra	LITAF	Q99732	TNIP3	Homo sapiens	Q96KP6	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	RASSF3	Homo sapiens	Q86WH2	Anti Tag CoIP	33961781
Intra	LITAF	Q99732	RASSF3	Homo sapiens	Q86WH2	Y2H Array	32296183
Intra	LITAF	Q99732	RASSF3	Homo sapiens	Q86WH2	Anti Tag CoIP	28514442
Intra	LITAF	Q99732	RASSF3	Homo sapiens	Q86WH2	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	TSG101	Homo sapiens	Q99816	Anti Tag CoIP	16118794
Intra	LITAF	Q99732	TSG101	Homo sapiens	Q99816	Anti Bait CoIP	16118794
Intra	LITAF	Q99732	UBA52	Homo sapiens	P62987	Y2H Array	32296183
Intra	LITAF	Q99732	UBA52	Homo sapiens	P62987	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	RPS27A	Homo sapiens	P62979	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	RPS27A	Homo sapiens	P62979	Y2H Array	32296183
Intra	LITAF	Q99732	TNIP1	Homo sapiens	Q15025	Y2H Array	32296183
Intra	LITAF	Q99732	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	BASP1	Homo sapiens	P80723	Y2H Pooling	32814053
Intra	LITAF	Q99732	BASP1	Homo sapiens	P80723	Validated Y2H	32814053
Intra	LITAF	Q99732	BASP1	Homo sapiens	P80723	Y2H Array	32814053
Intra	LITAF	Q99732	STAM2	Homo sapiens	O75886	Validated Y2H	25910212
Intra	LITAF	Q99732	STAM2	Homo sapiens	O75886	Y2H Bait-Prey Pool	25910212
Intra	LITAF	Q99732	STAM2	Homo sapiens	O75886	Y2H Array	25910212
Intra	LITAF	Q99732	STAM2	Homo sapiens	O75886	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	STAM2	Homo sapiens	O75886	Y2H Array	32296183
Intra	LITAF	Q99732	CAPN10	Homo sapiens	Q9HC96	Y2H Array	32814053
Intra	LITAF	Q99732	CAPN10	Homo sapiens	Q9HC96	Validated Y2H	32814053
Intra	LITAF	Q99732	CAPN10	Homo sapiens	Q9HC96	Y2H Pooling	32814053
Intra	LITAF	Q99732	DAPP1	Homo sapiens	Q9UN19	Y2H Pooling	32814053
Intra	LITAF	Q99732	DAPP1	Homo sapiens	Q9UN19	Validated Y2H	32814053
Intra	LITAF	Q99732	DAPP1	Homo sapiens	Q9UN19	Y2H Array	32814053
Intra	LITAF	Q99732	WWOX	Homo sapiens	Q9NZC7	IF	15064722
Intra	LITAF	Q99732	WWOX	Homo sapiens	Q9NZC7	Far-WB	15064722
Intra	LITAF	Q99732	WWOX	Homo sapiens	Q9NZC7	Pull Down	15064722
Intra	LITAF	Q99732	HIP1	Homo sapiens	O00291	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	HIP1	Homo sapiens	O00291	Y2H Array	32296183
Intra	LITAF	Q99732	N4BP1	Homo sapiens	O75113	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	N4BP1	Homo sapiens	O75113	Y2H Array	32296183
Intra	LITAF	Q99732	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	LITAF	Q99732	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	LITAF	Q99732	NEDD4	Homo sapiens	P46934	Anti Tag CoIP	33961781
Intra	LITAF	Q99732	NEDD4	Homo sapiens	P46934	Anti Tag CoIP	16118794
Intra	LITAF	Q99732	NEDD4	Homo sapiens	P46934	Anti Bait CoIP	16118794
Intra	LITAF	Q99732	NEDD4	Homo sapiens	P46934	Pull Down	27927196
Intra	LITAF	Q99732	NEDD4	Homo sapiens	P46934	NMR	27927196
Intra	LITAF	Q99732	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25910212
Intra	LITAF	Q99732	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	LITAF	Q99732	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25910212
Intra	LITAF	Q99732	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	LITAF	Q99732	CALCOCO2	Homo sapiens	Q13137	Y2H Bait-Prey Pool	25910212
Intra	LITAF	Q99732	HGS	Homo sapiens	O14964	Validated Y2H	25910212
Intra	LITAF	Q99732	HGS	Homo sapiens	O14964	Y2H Prey Pooling	25416956
Intra	LITAF	Q99732	HGS	Homo sapiens	O14964	Y2H Array	25910212
Intra	LITAF	Q99732	HGS	Homo sapiens	O14964	Validated Y2H	25416956
Intra	LITAF	Q99732	HGS	Homo sapiens	O14964	Y2H Bait-Prey Pool	25910212
Intra	LITAF	Q99732	VSNL1	Homo sapiens	P62760	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	VSNL1	Homo sapiens	P62760	Y2H Array	32296183
Intra	LITAF	Q99732	HPCAL4	Homo sapiens	Q9UM19	Anti Tag CoIP	28514442
Intra	LITAF	Q99732	HPCAL4	Homo sapiens	Q9UM19	Validated Y2H	32296183
Intra	LITAF	Q99732	HPCAL4	Homo sapiens	Q9UM19	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	HPCAL4	Homo sapiens	Q9UM19	Y2H Array	32296183
Intra	LITAF	Q99732	HPCAL4	Homo sapiens	Q9UM19	Anti Tag CoIP	33961781
Intra	LITAF	Q99732	BAG3	Homo sapiens	O95817	Y2H Array	25416956
Intra	LITAF	Q99732	HPCAL1	Homo sapiens	P37235	Y2H Array	32296183
Intra	LITAF	Q99732	HPCAL1	Homo sapiens	P37235	MAPPIT	32296183
Intra	LITAF	Q99732	HPCAL1	Homo sapiens	P37235	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	NCALD	Homo sapiens	P61601	Y2H Array	32296183
Intra	LITAF	Q99732	NCALD	Homo sapiens	P61601	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	REEP6	Homo sapiens	Q96HR9	Validated Y2H	25416956
Intra	LITAF	Q99732	REEP6	Homo sapiens	Q96HR9	Validated Y2H	25910212
Intra	LITAF	Q99732	REEP6	Homo sapiens	Q96HR9	Y2H Bait-Prey Pool	25910212
Intra	LITAF	Q99732	REEP6	Homo sapiens	Q96HR9	Y2H Array	25416956
Intra	LITAF	Q99732	REEP6	Homo sapiens	Q96HR9	Y2H Array	25910212
Intra	LITAF	Q99732	RNF208	Homo sapiens	Q9H0X6	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	RNF208	Homo sapiens	Q9H0X6	Validated Y2H	32296183
Intra	LITAF	Q99732	RNF208	Homo sapiens	Q9H0X6	Y2H Array	32296183
Intra	LITAF	Q99732	CBX1	Homo sapiens	P83916	Validated Y2H	32814053
Intra	LITAF	Q99732	CBX1	Homo sapiens	P83916	Y2H Array	32814053
Intra	LITAF	Q99732	CBX1	Homo sapiens	P83916	Y2H Pooling	32814053
Intra	LITAF	Q99732	OPTN	Homo sapiens	Q96CV9-2	Validated Y2H	25910212
Intra	LITAF	Q99732	OPTN	Homo sapiens	Q96CV9-2	Y2H Bait-Prey Pool	25910212
Intra	LITAF	Q99732	OPTN	Homo sapiens	Q96CV9-2	Y2H Array	25910212
Intra	LITAF	Q99732	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	LITAF	Q99732	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	LITAF	Q99732	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	LITAF	Q99732	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	LITAF	Q99732	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Charcot-Marie-Tooth Disease, Demyelinating, Type 1c	Charcot-Marie-Tooth Disease Type 1c CMT1C Hmsn1c Hmsn Ic Charcot-Marie-Tooth Disease, Type 1c Charcot-Marie-Tooth Neuropathy Type 1c Cmt, Slow Nerve Conduction Type C Charcot-Marie-Tooth Neuropathy, Type 1c Neuropathy, Hereditary Motor And Sensory, Type Ic Cmt Slow Nerve Conduction Type C Neuropathy Hereditary Motor And Sensory Type 1c Charcot-Marie-Tooth Disease 1c Charcot-Marie-Tooth Disease Demyelinating Type 1c Hereditary Motor And Sensory Neuropathy Ic Charcot-Marie-Tooth Disease, Type Ic
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Tooth Disease	Tooth Diseases Teeth Disease Tooth Disorders
Charcot-Marie-Tooth Disease And Deafness	Charcot-Marie-Tooth Disease Type 1e CMT1E Charcot-Marie-Tooth Disease Type 1 Hereditary Motor And Sensory Neuropathy Type 1 Charcot-Marie-Tooth Disease, Demyelinating, Type 1e Charcot-Marie-Tooth Disease, Type I Charcot-Marie-Tooth Neuropathy And Deafness, Autosomal Dominant Charcot-Marie-Tooth Disease, Type 1e Charcot-Marie-Tooth Disease Demyelinating Type 1e Autosomal Dominant Demyelinating Charcot-Marie-Tooth Disease Cmt1 Charcot-Marie-Tooth Neuropathy Type 1 Autosomal Dominant Charcot-Marie-Tooth Neuropathy And Deafness Charcot-Marie-Tooth Disease-Deafness Charcot-Marie-Tooth Type 1 Hmsn1 Hereditary Motor And Sensory Neuropathy 1 Cmt 1e Charcot Marie Tooth Disease Type 1e Charcot-Marie-Tooth Disease-Deafness Syndrome Charcot-Marie-Tooth Disease-Hearing Loss Syndrome Charcot-Marie-Tooth Disease 1e Charcot-Marie-Tooth Disease And Deafness Autosomal Dominant Charcot-Marie-Tooth Neuropathy Type 1e Charcot-Marie-Tooth Disease, Type Ie Hereditary Motor And Sensory Neuropathy Type I
Charcot-Marie-Tooth Disease Type 1g	Pmp2-Related Charcot-Marie-Tooth Disease Type 1 Pmp2-Related Charcot-Marie-Tooth Neuropathy Type 1 Pmp2-Related Cmt1 Pmp2-Related Hereditary Motor And Sensory Neuropathy Type 1 Cmt1g
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Charcot-Marie-Tooth Disease, Axonal, Type 2p	CMT2P Charcot-Marie-Tooth Disease Axonal Type 2p Charcot-Marie-Tooth Disease Type 2p Charcot-Marie-Tooth Neuropathy, Type 2p Charcot-Marie-Tooth Disease, Axonal, Type 2g, Formerly Cmt2g, Formerly Charcot-Marie-Tooth Neuropathy Type 2p Charcot-Marie-Toothe Disease, Axonal, Type 2p Charcot-Marie-Tooth Disease 2p Charcot-Marie-Tooth Disease, Axonal Type 2g Charcot-Marie-Tooth Neuropathy Axonal Type 2p Cmt2g Charcot-Marie-Tooth Disease, Type 2p Charcot-Marie-Tooth Disease, Axonal, Type 2g
Neuropathy, Hereditary, With Liability To Pressure Palsies	Tomaculous Neuropathy Hereditary Neuropathy With Liability To Pressure Palsies HNPP Polyneuropathy, Familial Recurrent Neuropathy, Recurrent, With Pressure Palsies Current Pressure-Sensitive Neuropathy Familial Recurrent Polyneuropathy Heterozygous Microdeletion 17p11.2p12 Potato-Grubbing Palsy Tulip-Bulb Digger'S Palsy Compression Neuropathy Entrapment Neuropathy Familial Pressure Sensitive Neuropathy Hereditary Motor And Sensory Neuropathy Hereditary Pressure Sensitive Neuropathy Inherited Tendency To Pressure Palsies Hereditary Liability To Pressure Palsies Nerve Compression Syndrome Entrapment Neuropathies Hereditary Motor And Sensory Neuropathies
Charcot-Marie-Tooth Disease, Demyelinating, Type 1a	Charcot-Marie-Tooth Disease Type 1a CMT1A Charcot-Marie-Tooth Disease, Type Ia Hmsn1a Hereditary Motor And Sensory Neuropathy Ia Hmsn Ia Charcot-Marie-Tooth Neuropathy, Type 1a Charcot-Marie-Tooth Disease, Type 1a Charcot-Marie-Tooth Neuropathy Type 1a Hereditary Motor And Sensory Neuropathy 1a Microduplication 17p12 Charcot-Marie-Tooth Disease, Autosomal Dominant, With Focally Folded Myelin Sheaths, Type 1a Autosomal Dominant Charcot-Marie-Tooth Disease With Focally Folded Myelin Sheaths Type 1a Cmt 1a Charcot Marie Tooth Disease Type 1a Hmsn 1a Charcot-Marie-Tooth Disease 1a Charcot-Marie-Tooth Disease Demyelinating Type 1a Charcot-Marie-Tooth Disease Slow Nerve Conduction Type Unlinked To Duffy
Charcot-Marie-Tooth Disease, Demyelinating, Type 1f	Charcot-Marie-Tooth Disease Type 1f CMT1F Charcot-Marie-Tooth Disease, Type 1f Charcot-Marie-Tooth Neuropathy Type 1f Charcot-Marie-Tooth Neuropathy, Type 1f Charcot-Marie-Tooth Disease Type 2b5 Ar-Cmt2b5 Autosomal Recessive Charcot-Marie-Tooth Disease Type 2b5 Seoan Due To Nefl Deficiency Severe Early-Onset Axonal Neuropathy Due To Nefl Deficiency Severe Early-Onset Axonal Neuropathy Due To Light Neurofilament Subunit Deficiency Charcot-Marie-Tooth Disease 1f Charcot-Marie-Tooth Disease Demyelinating Type 1f Charcot-Marie-Tooth Disease, Type If
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive	Charcot-Marie-Tooth Disease Type 4 Charcot-Marie-Tooth Disease Type 4e Hereditary Motor And Sensory Neuropathy Cmt4e CHN1 Hypomyelinating Neuropathy, Congenital, 1 Charcot-Marie-Tooth Neuropathy Type 4e Neuropathy, Congenital Hypomyelinating, 1 Ar-Cmt1 Autosomal Recessive Demyelinating Charcot-Marie-Tooth Cmt4 Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive Hypomyelination, Severe Congenital Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy Autosomal Recessive Congenital Hypomyelinating Neuropathy Congenital Amyelinating Neuropathy Congenital Hypomyelinating Neuropathy Autosomal Recessive Neuropathy, Congenital Hypomyelinating Or Amyelinating Severe Congenital Hypomyelination Hereditary Sensory Motor Neuropathy Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive Neuropathy, Hypomyelinating, Congenital, Type 1 Neuropathy, Motor And Sensory, Hereditary Congenital Hypomyelinating Neuropathy Hereditary Motor And Sensory Neuropathies Hereditary Sensorimotor Neuropathy Hmsn - [Hereditary Motor And Sensory Neuropathy] Hsmn - [Hereditary Sensory And Motor Neuropathy] Hereditary Motor And Sensory Neuropathy, Types I-Iv
Neuropathy	Peripheral Neuropathy Peripheral Neuropathies
Sensory Peripheral Neuropathy	Sensory Neuropathy Peripheral Sensory Neuropathy Hereditary Sensory And Autonomic Neuropathies
Charcot-Marie-Tooth Disease, Demyelinating, Type 1d	Charcot-Marie-Tooth Disease Type 1d CMT1D Hmsn Id Hmsn1d Charcot-Marie-Tooth Disease, Type 1d Hereditary Motor And Sensory Neuropathy 1d Charcot-Marie-Tooth Neuropathy Type 1d Charcot-Marie-Tooth Neuropathy, Type 1d Charcot-Marie-Tooth Disease 1d Charcot-Marie-Tooth Disease Demyelinating Type 1d Hereditary Motor And Sensory Neuropathy Id Charcot-Marie-Tooth Disease, Type Id
Peroneal Neuropathy	Peroneal Neuropathies
Charcot-Marie-Tooth Disease, Type 4c	Charcot-Marie-Tooth Disease Type 4c CMT4C Charcot-Marie-Tooth Neuropathy Type 4c Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4c Charcot-Marie-Tooth Neuropathy, Type 4c Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4c Charcot-Marie-Tooth Disease 4c Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4c
Charcot-Marie-Tooth Disease, X-Linked Recessive, 2	CMTX2 Charcot-Marie-Tooth Disease X-Linked Recessive 2 X-Linked Charcot-Marie-Tooth Disease Type 2 Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 2 Charcot-Marie-Tooth Neuropathy X-Linked Recessive 2 Charcot-Marie-Tooth Disease, X-Linked Type 2, Recessive
Charcot-Marie-Tooth Disease, Demyelinating, Type 1b	Charcot-Marie-Tooth Disease Type 1b CMT1B Hereditary Motor And Sensory Neuropathy Ib Hmsn Ib Hmsn1b Peroneal Muscular Atrophy Charcot-Marie-Tooth Disease, Type 1b Charcot-Marie-Tooth Disease Slow Nerve Conduction Type Linked To Duffy Charcot-Marie-Tooth Neuropathy Type 1b Charcot-Marie-Tooth Disease, Type Ib Hereditary Motor And Sensory Neuropathy I Hmsn I Hmsn1 Charcot-Marie-Tooth Neuropathy, Type 1b Charcot-Marie-Tooth Disease, Slow Nerve Conduction Type, Linked To Duffy Charcot-Marie-Tooth Disease, Autosomal Dominant, With Focally Folded Myelin Sheaths, Type 1b Autosomal Dominant Charcot-Marie-Tooth Disease With Focally Folded Myelin Sheaths Type 1b Charcot-Marie-Tooth Disease 1b Charcot-Marie-Tooth Disease Demyelinating Type 1b Hmsn Type I Hereditary Motor And Sensory Neuropathy Type I Charcot-Marie-Tooth Disease
Neuropathy, Hereditary Sensory And Autonomic, Type Ic	HSAN1C Hsan Ic Hsn1c Hsn Ic Hereditary Sensory And Autonomic Neuropathy Type 1c Neuropathy, Hereditary Sensory And Autonomic, Type 1c Neuropathy, Hereditary Sensory, Type Ic Hereditary Sensory And Autonomic Neuropathy Type Ic Neuropathy, Hereditary Sensory And Autonomic, 1c Hereditary Sensory Neuropathy Type Ic Neuropathy, Hereditary Sensory/Autonomic, Type Ic Neuropathy, Sensory And Autonomic, Hereditary, Type Ic
Charcot-Marie-Tooth Disease, Type 4j	Charcot-Marie-Tooth Disease Type 4j CMT4J Charcot-Marie-Tooth Disease, Autosomal Recessive, Type 4j Autosomal Recessive Charcot-Marie-Tooth Disease Type 4j Charcot-Marie-Tooth Disease 4j
Polyneuropathy	Polyneuropathies
Charcot-Marie-Tooth Disease, X-Linked Dominant, 1	CMTX1 Cmtx Charcot-Marie-Tooth Disease X-Linked Dominant 1 Charcot-Marie-Tooth Neuropathy, X-Linked Dominant, 1 X-Linked Charcot-Marie-Tooth Disease Charcot-Marie-Tooth Peroneal Muscular Atrophy, X-Linked Cmt1x X-Linked Charcot-Marie-Tooth Disease Type 1 X-Linked Hereditary Motor And Sensory Neuropathy Hereditary Motor And Sensory Neuropathy, X-Linked Hmsn, X-Linked Charcot-Marie-Tooth Neuropathy, X-Linked, 1 Cmt2, Formerly Charcot-Marie-Tooth Neuropathy X-Linked Dominant 1 Charcot-Marie-Tooth Neuropathy X-Linked 1 Charcot-Marie-Tooth Peroneal Muscular Atrophy X-Linked Hereditary Motor And Sensory Neuropathy X-Linked Hmsn X-Linked Charcot-Marie-Tooth, X-Linked Charcot-Marie-Tooth Disease, X-Linked Dominant, Type 1 Charcot-Marie-Tooth Disease, X-Linked, 1
Charcot-Marie-Tooth Disease, Demyelinating, Type 4f	Charcot-Marie-Tooth Disease Type 4f CMT4F Charcot-Marie-Tooth Disease, Type 4f Charcot-Marie-Tooth Disease 4f Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4f Charcot-Marie-Tooth Neuropathy Type 4f Dejerine-Sottas Disease
Hypertrophic Neuropathy Of Dejerine-Sottas	Dejerine-Sottas Disease Dejerine-Sottas Syndrome Charcot-Marie-Tooth Disease Type 3 DSS Hereditary Motor And Sensory Neuropathy Type Iii Hmsn3 Dejerine-Sottas Neuropathy Hmsn Iii Charcot-Marie-Tooth Disease, Type 3 Cmt3 Dsn Hmsn 3 Hereditary Motor And Sensory Neuropathy Type 3 Hereditary Motor And Sensory Neuropathy 3 Hypertrophic Neuropathy Of Infancy Charcot-Marie-Tooth Disease Demyelinating Type 4f Charcot-Marie-Tooth Disease Type 4f Charcot-Marie-Tooth Neuropathy Type 4f Cmt4f Hereditary Motor And Sensory Neuropathy Iii Charcot-Marie-Tooth Disease, Demyelinating, Type 4f
Neuronopathy, Distal Hereditary Motor, Type Iic	HMN2C Hmn Iic Dhmn2c Distal Hereditary Motor Neuronopathy Type 2c Distal Hereditary Motor Neuropathy Type Iic Neuronopathy, Distal Hereditary Motor, Type 2c Neuropathy, Distal Hereditary Motor, Type Iic Neuronopathy, Distal Hereditary Motor, 2c Dhmn Iic Neuropathy, Motor, Distal, Hereditary, Type 2c
Charcot-Marie-Tooth Disease, Type 4b1	Charcot-Marie-Tooth Disease Type 4b1 CMT4B1 Cmt4b Charcot-Marie-Tooth Neuropathy Type 4b1 Charcot-Marie-Tooth Disease Type 4b Charcot-Marie-Tooth Disease, Autosomal Recessive, With Focally Folded Myelin Sheaths, Autosomal Recessive, Type 4b1 Charcot-Marie-Tooth Neuropathy, Type 4b1 Charcot-Marie-Tooth Disease, Type 4b Autosomal Recessive Charcot-Marie-Tooth Disease With Focally Folded Myelin Sheaths Type 4b1 Charcot-Marie-Tooth Disease 4b1 Charcot-Marie-Tooth Disease Autosomal Recessive With Focally Folded Myelin Sheaths 4b1 Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4b1
Charcot-Marie-Tooth Disease, Type 4b2	Charcot-Marie-Tooth Disease Type 4b2 CMT4B2 Charcot-Marie-Tooth Disease, With Focally Folded Myelin Sheaths, Autosomal Recessive, Type 4b2 Charcot-Marie-Tooth Neuropathy, Type 4b2 Charcot-Marie-Tooth Neuropathy Type 4b2 Autosomal Recessive Charcot-Marie-Tooth Disease With Focally Folded Myelin Sheaths Type 4b2 Cmt 4b2 Charcot Marie Tooth Disease Type 4b2 Charcot-Marie-Tooth Disease 4b2 Charcot-Marie-Tooth Disease Autosomal Recessive With Focally Folded Myelin Sheaths 4b2 Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4b2
Charcot-Marie-Tooth Disease, Dominant Intermediate B	CMTDIB Charcot-Marie-Tooth Disease Dominant Intermediate B Di-Cmtb Cmtdi1 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2m Charcot-Marie-Tooth Neuropathy Dominant Intermediate B CMT2M Charcot-Marie-Tooth Neuropathy, Dominant Intermediate B Charcot-Marie-Tooth Disease, Axonal Type 2m Autosomal Dominant Intermediate Charcot-Marie-Tooth Disease Type B Charcot-Marie-Tooth Disease 2m Charcot-Marie-Tooth Disease Axonal Autosomal Dominant Type 2m Charcot-Marie-Tooth Disease Axonal Type 2m Charcot-Marie-Tooth Neuropathy Axonal Type 2m Charcot-Marie-Tooth Disease, Dominant, Intermediate Type, B Charcot-Marie-Tooth Disease, Axonal, Type 2m Charcot-Marie-Tooth Disease, Dominant Intermediate, Type B
Charcot-Marie-Tooth Disease, Type 4d	Charcot-Marie-Tooth Disease Type 4d CMT4D Hmsnl Hmsn4d Charcot-Marie-Tooth Neuropathy Type 4d Hereditary Motor And Sensory Neuropathy Lom Type Hmsn-Lom Neuropathy, Hereditary Motor And Sensory, Lom Type Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4d Charcot-Marie-Tooth Neuropathy, Type 4d Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4d Hmsn Lom Type Hmsn, Lom Type Hereditary Motor And Sensory Neuropathy, Lom Type Charcot-Marie-Tooth Disease 4d Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4d Hereditary Motor And Sensory Neuropathy Ivd Hmsn Ivd
Charcot-Marie-Tooth Disease Type X
Charcot-Marie-Tooth Disease, Type 4h	Charcot-Marie-Tooth Disease Type 4h CMT4H Charcot-Marie-Tooth Neuropathy Type 4h Charcot-Marie-Tooth Disease, Autosomal Recessive, Type 4h Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4h Charcot-Marie-Tooth Neuropathy, Type 4h Autosomal Recessive Charcot-Marie-Tooth Disease Type 4h Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4h Charcot-Marie-Tooth Disease 4h Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4h
Charcot-Marie-Tooth Disease, Axonal, Type 2f	Charcot-Marie-Tooth Disease Axonal Type 2f CMT2F Charcot-Marie-Tooth Disease, Neuronal, Type 2f Charcot-Marie-Tooth Neuropathy, Type 2f Autosomal Dominant Charcot-Marie-Tooth Disease Type 2f Charcot-Marie-Tooth Neuropathy Type 2f Charcot-Marie-Tooth Neuronal Type 2f Charcot-Marie-Tooth Disease Type 2f Cmt 2f Charcot Marie Tooth Disease Type 2f Charcot-Marie-Tooth Disease 2f Charcot-Marie-Tooth Disease Neuronal Type 2f Charcot-Marie-Tooth Disease, Type 2f
Charcot-Marie-Tooth Disease, Type 4a	Charcot-Marie-Tooth Disease Type 4a CMT4A Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4a Charcot-Marie-Tooth Neuropathy, Type 4a Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4a Charcot-Marie-Tooth Neuropathy Type 4a Charcot-Marie-Tooth Disease 4a Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive, Type 4a Charcot-Marie-Tooth Disease Neuropathy Type 4a
Cortical Dysplasia, Complex, With Other Brain Malformations 6	Complex Cortical Dysplasia With Other Brain Malformations 6 CDCBM6 Cdcbm56 Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6
Charcot-Marie-Tooth Disease, Type 4b3	Charcot-Marie-Tooth Disease Type 4b3 CMT4B3 Charcot-Marie-Tooth Disease With Focally Folded Myelin Charcot-Marie-Tooth Disease 4b3 Charcot-Marie-Tooth Neuropathy Type 4b3
Charcot-Marie-Tooth Disease, Axonal, Type 2b	Charcot-Marie-Tooth Disease Type 2b CMT2B Hmsn Iib Hmsn2b Charcot-Marie-Tooth Disease, Type 2b Hereditary Motor And Sensory Neuropathy Iib Autosomal Dominant Charcot-Marie-Tooth Disease Type 2b Charcot-Marie-Tooth Neuropathy Type 2b Charcot-Marie-Tooth Disease, Autosomal Dominant, Type 2b Charcot-Marie-Tooth Neuropathy, Type 2b Hereditary Motor And Sensory Nueropathy Iib Cmt 2b Charcot Marie Tooth Disease Type 2b Charcot-Marie-Tooth Disease, Neuronal, Type 2b Hereditary Motor And Sensory Neuropathy 2 B Peripheral Sensory Neuropathy, Autosomal Dominant Charcot-Marie-Tooth Disease 2b Charcot-Marie-Tooth Disease Axonal Type 2b Charcot-Marie-Tooth Disease Neuronal Type 2b Peripheral Sensory Neuropathy Autosomal Dominant Psn
Friedreich Ataxia	Friedreich Ataxia 1 FRDA Friedreich Ataxia With Retained Reflexes Frda1 Fa Friedreich'S Ataxia Hereditary Spinal Ataxia Fa1 Friedreich'S Tabes Hereditary Spinal Sclerosis Spinocerebellar Ataxia, Friedreich Friedreich Spinocerebellar Ataxia Friedrich'S Ataxia
Neuropathy, Hereditary Sensory And Autonomic, Type Iia	Hereditary Sensory And Autonomic Neuropathy Type 2 Hsan2 HSAN2A Morvan Disease Hereditary Sensory And Autonomic Neuropathy Type Ii Neurogenic Acroosteolysis Hsan Iia Hsn2a Hsn Iia Neuropathy, Progressive Sensory, Of Children Neuropathy, Congenital Sensory Neuropathy, Hereditary Sensory And Autonomic, Type Ii Hereditary Sensory And Autonomic Neuropathy Type 2a Hereditary Sensory And Autonomic Neuropathy Type Iia Hsanii Congenital Sensory Neuropathy Hsan Type Ii Morvan Syndrome Neuropathy, Hereditary Sensory And Autonomic, Type 2a Morvan'S Disease Neuropathy, Hereditary Sensory, Type Iia Acroosteolysis, Neurogenic Acroosteolysis, Giaccai Type Neuropathy, Hereditary Sensory Radicular, Autosomal Recessive Hereditary Sensory Autonomic Neuropathy Type 2 Giaccai Type Acroosteolysis Hereditary Sensory Neuropathy Type 2 Hereditary Sensory Radicular Neuropathy, Recessive Form Hsan2b Hsan2c Hsan2d Hsn Type Ii Autosomal Recessive Sensory Radicular Neuropathy Limbic Encephalitis-Neuromyotonia-Hyperhidrosis-Polyneuropathy Syndrome Morvan Fibrillary Chorea Neuropathy, Hereditary Sensory And Autonomic, 2a Acroosteolysis Giaccai Type Hereditary Sensory Neuropathy Type Iia Hereditary Sensory Radicular Neuropathy Autosomal Recessive Progressive Sensory Neuropathy Of Children Neuropathy Congenital Sensory Charcot-Marie-Tooth Disease Neuropathy, Sensory And Autonomic, Hereditary, Type Iia Hereditary Sensory Autonomic Neuropathy, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii Sensory Neuropathy, Hereditary Neuropathy, Hereditary Sensory And Autonomic, Type Iib
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS07697	LITAF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20980	Litaf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27497	Litaf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	LITAF	MGD	MGI:1929512
Felis catus	LITAF	VGNC	VGNC:107759
Rattus norvegicus	LITAF	RGD	RGD:69294
Bos taurus	LITAF	VGNC	VGNC:30911
Others	LITAF	NCBI