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製品番号: HY-N19214

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Glenthmycin L

Glenthmycin L is a potent antibiotic that can be found in Australian sheep pasture-derived Streptomyces sp. CMB-PB041. Glenthmycin L exhibits antibacterial activity against Gram-positive bacterial pathogens including Staphylococcus aureus, Enterococcus faecalis, Methicillin (HY-B0974)-resistant Staphylococcus aureus, and Vancomycin (HY-B0671)-resistant Enterococci. Glenthmycin L can be used for the research of bacterial infections caused by Gram-positive pathogens.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3040055-91-9
分子式: C₃₅H₄₆O₆
分子量:562.75

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Glenthmycin L 構造式

CAS 番号: 3040055-91-9

容量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Antibiotic アイソフォーム固有の製品をすべて表示 :

体外実験

Glenthmycin L (0.01-30 μM; 16-24 h) potently inhibits growth of Staphylococcus aureus (ATCC 25923) with an IC₅₀ of 0.8 μM, methicillin-resistant S. aureus (ATCC 43300) with an IC₅₀ of 0.3 μM, Enterococcus faecalis with an IC₅₀ of 3.0 μM, methicillin-resistant S. aureus (ATCC 33591) with an IC₅₀ of 6.8 μM, and vancomycin-resistant Enterococci with an IC₅₀ of 6.7 μM^[1].
Glenthmycin L (30 μM; 48 h) shows no significant cytotoxicity against SW620 human colorectal carcinoma cells or NCI-H460 human lung carcinoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

SW620 human colorectal carcinoma cells, NCI-H460 human lung carcinoma cells
Concentration:

30 μM
Incubation Time:

48 h
Result:

Did not exhibit significant cytotoxicity against SW620 or NCI-H460 cells.
Showed no indication of reduced cell viability relative to the negative control.

化学情報

CAS 番号 3040055-91-9
分子量 562.75
分子式 C₃₅H₄₆O₆
SMILES

OC=1[C@@]23[C@@](C=C(C)[C@H](C)C2)(/C=C(\C)/CC/C=C(\C)/[C@]4([C@@](C)(C(=O)C1C(=O)O3)[C@]5([C@@]([C@@H](OC(C)=O)CC[C@@H]5C)(C=C4C)[H])[H])[H])[H]
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces sp.
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Wu T, et al. Glenthmycins A-M: Macrocyclic Spirotetronate Polyketide Antibacterials from the Australian Pasture Plant-Derived Streptomyces sp. CMB-PB041. J Nat Prod. 2022 Jun 24;85(6):1641-1657. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Glenthmycin L

Antibiotic アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Glenthmycin L 関連分類

HY-N19214 関連分類