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製品番号: HY-149474

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HDAC-IN-63

HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC₅₀: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively). HDAC-IN-63 inhibits MV4-11 cell proliferation (IC₅₀: 92 nM. HDAC-IN-63 induces apoptosis and arrests cell cycle in MV4-11 cells. HDAC-IN-63 can be used for research of acute myeloid leukemia (AML).

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CAS 番号: 2920046-95-1
分子式: C₂₅H₂₆Cl₂N₆O₃
分子量:529.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

HDAC-IN-63 構造式

CAS 番号: 2920046-95-1

容量

価格（税別）

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

0.844 and 30.0 nM for FLT3 and HDAC1^[1]

HDAC アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MOLM-13	IC₅₀	0.142 μM Compound: 63	Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay	[PMID: 37659198]
MOLM-13	IC₅₀	142 nM Compound: 21	Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as reduction in cell viability incubated for 48 hr by CellTiter-Glo assay Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as reduction in cell viability incubated for 48 hr by CellTiter-Glo assay	[PMID: 39094274]
MV4-11	IC₅₀	0.092 μM Compound: 63	Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay	[PMID: 37659198]
MV4-11	IC₅₀	92 nM Compound: 21	Antiproliferative activity against human MV4-11 cells assessed as reduction in cell growth Antiproliferative activity against human MV4-11 cells assessed as reduction in cell growth	[PMID: 39094274]
U-937	IC₅₀	4.538 μM Compound: 63	Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay	[PMID: 37659198]

化学情報

CAS 番号 2920046-95-1
分子量 529.42
分子式 C₂₅H₂₆Cl₂N₆O₃
SMILES

ClC1=CC=CC(Cl)=C1CN(C=N2)C3=C2C=CC(C4=CC(NC(CCCCCCC(NO)=O)=O)=NN4)=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang Z, et al. Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy. Eur J Med Chem. 2023 Aug 28;260:115759. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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HDAC-IN-63

HDAC アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

HDAC-IN-63 関連分類

HY-149474 関連分類