LA1011
LA1011 is a heat shock protein (Hsps) co-inducer that selectively enhances heat shock-induced Hsp70, Hsp40, and Hsp27 expression. LA1011 exhibits neuroprotective effects in APPxPS1 transgenic Alzheimer's disease mice, preventing hippocampal neuronal loss, reducing tau pathology and neurofibrillary tangle accumulation in the hippocampus, decreasing amyloid plaque formation in the hippocampus, and increasing dendritic spine density in hippocampal CA1. LA1011 can be used for research on Alzheimer's disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1439268-65-1
- 分子式: C25H36Cl2F3N3O4
- 分子量:570.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
HSP70 |
HSP40 |
体外実験
LA1011 (5-10 µM) does not alter yeast Hsp90 ATPase activity[1].
LA1011 (5 µM; 30 min-17 h) co-induced Hsp70 promoter-driven YFP expression in SH-SY5Y-pHsp70-YFP cells under 42°C heat shock conditions[1].
LA1011 (5 µM; 1-16 h) selectively co-induces Hsp27, Hsp40, and Hsp70 in heat-shocked SH-SY5Y cells without altering Hsp levels under non-stressed conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells
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Concentration:5 µM
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Incubation Time:1 h (42°C heat shock); 16 h (37°C recovery)
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Result:Increased Hsp27, Hsp40, and Hsp70 levels under heat shock.
Did not alter Hsp27, Hsp40, Hsp70, Hsp60, or Hsp90 levels without heat shock.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B6C3-Tg (APPswe/PS1dE9)85Dbo/Mmjax (C57BL/6 genetic background; male; 3 months old at start)[1]
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Dosage:3 mg/kg
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Administration:i.p.; once daily; 6 months
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Result:Improved spatial learning and memory in the Morris water maze.
Required less time to find the platform than transgenic saline controls.
Prevented loss of hippocampal neurons.
Decreased the number of abnormally accumulated neurofibrillary tangles in the hippocampus to the level found in wild-type mice.
Increased dendritic spine number in hippocampal CA1 compared with transgenic saline controls.
Decreased amyloid plaque formation in the hippocampus.
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Animal Model:wild-type C57BL/6 (male; 3 months old at start)[1]
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Dosage:3 mg/kg
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Administration:i.p.; once daily; 6 months
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Result:Improved memory performance in the Morris water maze.
Required less time to complete the task than wild-type saline controls.
Did not affect dendritic spine number in wild-type mice.
化学情報
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CAS 番号 1439268-65-1
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分子量 570.47
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分子式 C25H36Cl2F3N3O4
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SMILES
O=C(C1=C(CCN(C)C)N(C)C(CCN(C)C)=C(C1C2=CC=C(C(F)(F)F)C=C2)C(OC)=O)OC.Cl.Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LA1011 関連分類
HY-129396 関連分類
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