Litoxetine
Litoxetine (SL 81.0385) is a selective 5-HT uptake inhibitor. Litoxetine is a 5-HT3 receptor antagonist with a Ki of 85 nM for cerebral 5-HT3 receptors. Litoxetine is an antidepressant and has antiemetic properties.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 86811-09-8
- 分子式: C16H19NO
- 分子量:241.33
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1.3 μM
Compound: Litoxetine
|
Inhibition of radiolabeled dopamine reuptake at human DAT expressed in HEK293 cells
Inhibition of radiolabeled dopamine reuptake at human DAT expressed in HEK293 cells
|
[PMID: 19282174] |
| HEK293 | IC50 |
1.4 μM
Compound: 4
|
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting
|
[PMID: 19740658] |
| HEK293 | IC50 |
5.9 nM
Compound: 4
|
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting
|
[PMID: 19740658] |
| HEK293 | IC50 |
6 nM
Compound: Litoxetine
|
Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cells
Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cells
|
[PMID: 19282174] |
| HEK293 | IC50 |
6.5 μM
Compound: Litoxetine
|
Inhibition of radiolabeled noradrenaline reuptake at human NET expressed in HEK293 cells
Inhibition of radiolabeled noradrenaline reuptake at human NET expressed in HEK293 cells
|
[PMID: 19282174] |
| HEK293 | IC50 |
6.7 μM
Compound: 4
|
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting
|
[PMID: 19740658] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 86811-09-8
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分子量 241.33
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分子式 C16H19NO
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SMILES
C1(COC2CCNCC2)=CC3=C(C=CC=C3)C=C1
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別名
SL 81.0385
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輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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