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製品番号: HY-119408

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MB725

MB725 is an ethylamide analogue of MB710 (HY-120373). MB725 increases mRNA levels of a range of p53 target genes, notably PUMA, p21, MDM2, NOXA and BAX. MB725 shows selective anticancer activity against p53-Y220C cancer.

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CAS 番号: 2230058-99-6
分子式: C₁₈H₂₁IN₄O₂S
分子量:484.36

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

MB725 構造式

CAS 番号: 2230058-99-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

^[1]

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Bcl-2 Family アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	18 μM Compound: MB725; 72	Antiproliferative activity against human BxPC3 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human BxPC3 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay	[PMID: 29702446]
Huh-7	IC₅₀	10 μM Compound: MB725; 72	Antiproliferative activity against human HuH7 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human HuH7 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay	[PMID: 29702446]
NUGC-3	IC₅₀	10 μM Compound: MB725; 72	Antiproliferative activity against human NUGC3 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human NUGC3 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay	[PMID: 29702446]
NUGC-4	IC₅₀	>120 μM Compound: MB725; 72	Antiproliferative activity against human NUGC4 cells harboring wild-type p53 after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human NUGC4 cells harboring wild-type p53 after 72 hrs by CellTiter-Glo assay	[PMID: 29702446]
SW1088	IC₅₀	>120 μM Compound: MB725; 72	Antiproliferative activity against human SW1088 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human SW1088 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay	[PMID: 29702446]
WI-38	IC₅₀	>120 μM Compound: MB725; 72	Antiproliferative activity against human WI38 cells after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human WI38 cells after 72 hrs by CellTiter-Glo assay	[PMID: 29702446]

化学情報

CAS 番号 2230058-99-6
分子量 484.36
分子式 C₁₈H₂₁IN₄O₂S
SMILES

O=C(NCC)C=1C(O)=C(I)C(=C2SC(=NC21)N(CC)CC)N3C=CC=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (284 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Baud MGJ, et al. Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem. 2018 May 25;152:101-114. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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MB725

Bcl-2 Family アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

Cellular Effect

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

MB725 関連分類

HY-119408 関連分類

Bioz

Keywords

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