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製品番号: HY-116294

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Methoctramine

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Methoctramine is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine can inhibit Muscarine (HY-121404)-induced bradycardia in vivo. Methoctramine can be used in the study of cardiovascular diseases.

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CAS 番号: 104807-40-1
分子式: C₃₆H₆₂N₄O₂
分子量:582.90

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (261 KB)

Methoctramine 構造式

CAS 番号: 104807-40-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

mAChR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Astrocyte	EC₅₀	0.0845 μM Compound: 31	Antiproliferative activity against mouse astrocyte cells by MTT assay Antiproliferative activity against mouse astrocyte cells by MTT assay	[PMID: 17417631]
HeLa	IC₅₀	>100 μM Compound: 1, methoctramine	Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by trypan blue exclusion assay Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by trypan blue exclusion assay	[PMID: 23887056]
Oocyte	IC₅₀	138 nM Compound: 1	Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-induced inward current at -70mV by two-electrode voltage clamp assay Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-induced inward current at -70mV by two-electrode voltage clamp assay	[PMID: 23692871]
Thymocyte	IC₅₀	>100 μM Compound: 1, methoctramine	Cytotoxicity against rat thymocytes assessed as cell survival after 24 hrs by trypan blue exclusion assay Cytotoxicity against rat thymocytes assessed as cell survival after 24 hrs by trypan blue exclusion assay	[PMID: 23887056]

化学情報

CAS 番号 104807-40-1
分子量 582.90
分子式 C₃₆H₆₂N₄O₂
SMILES

COC1=CC=CC=C1CNCCCCCCNCCCCCCCCNCCCCCCNCC2=CC=CC=C2OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Pharmaceuticals (Basel)

Ethanolic Extracts of Cupressaceae Species Conifers Provide Rapid Protection against Barium Chloride-Induced Cardiac Arrhythmia. [Abstract]

2024 Jul 29;17(8):1003. PMID: 39204108

純度とドキュメンテーション

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純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (261 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Jaiswal N, et, al. Methoctramine, a cardioselective antagonist: muscarinic receptor mediating prostaglandin synthesis in isolated rabbit heart. Eur J Pharmacol. 1991 Jan 3;192(1):63-70. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Methoctramine

1 Cited Publications

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生物活性
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化学情報
Publications (1)
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Methoctramine

MedChemExpress（MCE）の使用を引用している文献 Methoctramine

mAChR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Methoctramine 関連分類

HY-116294 関連分類