NAS-181
Based on 3 publication(s) in Google Scholar
NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions.
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- CAS 番号: 205242-62-2
- 分子式: C20H30N2O7S
- 分子量:442.53
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 NAS-181
More5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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5-HT1B Receptor |
NAS-181 (compound (R)-25) (0-1000 nM) increases the K+-stimulated release of [3H]-5-HT from rat occipital cortical slices[1].
NAS-181 (3 mg/kg; s.c.) increases in the number of wet dog shakes in rats, and the effect is abolished by pretreatment of the rats with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pCPA) (200 mg/kg; i.p.)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[1]
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Dosage:20 mg/kg
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Administration:S.c.
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Result:Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40−60%).
化学情報
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CAS 番号 205242-62-2
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分子量 442.53
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分子式 C20H30N2O7S
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SMILES
CS(=O)(O)=O.[C@H]1(COC2=C3C(C=C(CN4CCOCC4)CO3)=CC=C2)CNCCO1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Neurosci
Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety. [Abstract]2022 Dec;25(12):1651-1663. PMID: 36446933 -
Transl Neurodegener
Dorsal raphe nucleus-hippocampus serotonergic circuit underlies the depressive and cognitive impairments in 5×FAD male mice. [Abstract]2024 Jul 24;13(1):34. PMID: 39044270 -
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NAS-181 関連分類
HY-135507 関連分類
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