NAS-181
Based on 3 publication(s) in Google Scholar
NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions.
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- CAS 番号: 205242-62-2
- 分子式: C20H30N2O7S
- 分子量:442.53
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 NAS-181
More5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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5-HT1B Receptor |
体外実験
NAS-181 (compound (R)-25) (0-1000 nM) increases the K+-stimulated release of [3H]-5-HT from rat occipital cortical slices[1].
NAS-181 (3 mg/kg; s.c.) increases in the number of wet dog shakes in rats, and the effect is abolished by pretreatment of the rats with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pCPA) (200 mg/kg; i.p.)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[1]
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Dosage:20 mg/kg
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Administration:S.c.
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Result:Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40−60%).
化学情報
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CAS 番号 205242-62-2
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分子量 442.53
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分子式 C20H30N2O7S
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SMILES
CS(=O)(O)=O.[C@H]1(COC2=C3C(C=C(CN4CCOCC4)CO3)=CC=C2)CNCCO1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Neurosci
Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety. [Abstract]2022 Dec;25(12):1651-1663. PMID: 36446933 -
Transl Neurodegener
Dorsal raphe nucleus-hippocampus serotonergic circuit underlies the depressive and cognitive impairments in 5×FAD male mice. [Abstract]2024 Jul 24;13(1):34. PMID: 39044270 -
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (112.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
参考文献
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2597 mL | 11.2987 mL | 22.5973 mL | 56.4933 mL |
| 5 mM | 0.4519 mL | 2.2597 mL | 4.5195 mL | 11.2987 mL | |
| 10 mM | 0.2260 mL | 1.1299 mL | 2.2597 mL | 5.6493 mL | |
| 15 mM | 0.1506 mL | 0.7532 mL | 1.5065 mL | 3.7662 mL | |
| 20 mM | 0.1130 mL | 0.5649 mL | 1.1299 mL | 2.8247 mL | |
| 25 mM | 0.0904 mL | 0.4519 mL | 0.9039 mL | 2.2597 mL | |
| 30 mM | 0.0753 mL | 0.3766 mL | 0.7532 mL | 1.8831 mL | |
| 40 mM | 0.0565 mL | 0.2825 mL | 0.5649 mL | 1.4123 mL | |
| 50 mM | 0.0452 mL | 0.2260 mL | 0.4519 mL | 1.1299 mL | |
| 60 mM | 0.0377 mL | 0.1883 mL | 0.3766 mL | 0.9416 mL | |
| 80 mM | 0.0282 mL | 0.1412 mL | 0.2825 mL | 0.7062 mL | |
| 100 mM | 0.0226 mL | 0.1130 mL | 0.2260 mL | 0.5649 mL |
NAS-181 関連分類
HY-135507 関連分類
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