Nesvategrast
Nesvategrast (SF0166) is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1621332-91-9
- 分子式: C23H27F2N5O4
- 分子量:475.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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αvβ3 0.6 nM (IC50) |
αvβ6 8 nM (IC50) |
αvβ8 13 nM (IC50) |
Nesvategrast (0.5-4 μg; 12 days; chick chorioallantoic membrane (CAM) models) inhibits angiogenesis stimulated by basic fibroblast growth factor in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female 129SVE newborn mice with oxygen-induced retinopathy (OIR) models[1]
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Dosage:5% SF0166
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Administration:Bilateral eye topical drip 5% SF0166
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Result:Reduced new blood vessel formation.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1621332-91-9
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分子量 475.49
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分子式 C23H27F2N5O4
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SMILES
OC(C[C@@H](C1=CN=C(OC(F)F)C=C1)N2C(N(CCCC(N3)=CC=C4C3=NCCC4)CC2)=O)=O
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別名
SF0166
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Nesvategrast 関連分類
HY-117133 関連分類
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