NSC126188
NSC126188 is a RhoB inducer. NSC126188 can induce apoptosis by inhibiting Akt/FoxO3 signaling. NSC126188 can be used for the research of cancer, such as prostate cancer.
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- CAS 番号: 31863-82-8
- 分子式: C22H45IN2O
- 分子量:480.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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RhoB |
FOXO3 |
NSC126188 (1-10 μM, 1-12 h) inhibits proliferation (GI50 = 0.7 μM) and induces apoptosis in human prostate cancer PC-3 cells[1].
NSC126188 (5 μM, 1 h) significantly reduces the phosphorylation levels of Akt at S473 and T308 sites in PC-3 cells
NSC126188 (5 μM, 30 mins) completely blocks insulin-induced translocation of Akt to the plasma membrane in PC-3 cells transfected with GFP-Akt;
NSC126188 (5 μM, 3-9 h) induces dephosphorylation of FoxO3a and upregulates RhoB expressionin PC-3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-3 cells
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Concentration:1, 3, 5 and 10 μM
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Incubation Time:1, 3, 6, 9 and 12 h
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Result:Increased caspase-3, cleaved PARP, p21 and RhoB proteins.
Downregulated cyclin D1 levels.
化学情報
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CAS 番号 31863-82-8
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分子量 480.51
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分子式 C22H45IN2O
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SMILES
O=C(CCCCCCCCCCCCCCC)N1CC[N+](C)(CC1)C.[I-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NSC126188 関連分類
HY-176902 関連分類
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