Brains

DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to TfR. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease.

NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination.

DSPE-PEG2000-TAT is a cell-penetrating peptide-modified PEGylated phospholipid conjugate and cellular uptake enhancer. DSPE-PEG2000-TAT forms via conjugation of Cys-TAT to DSPE-PEG2000-Mal. DSPE-PEG2000-TAT enhances liposomal cellular uptake and siRNA transfection efficiency in glomerular mesangial and macrophage cells. DSPE-PEG2000-TAT can be used for drug delivery.

DSPE-PEG5000-RVG29 is a PEG compound which composed of DSPE and a Rabies virus glycoprotein 29 (RVG29). RVG29 can bind specifically to the nicotinic acetylcholine receptor (nAChR) at the blood-brain barrier (BBB) and cross over the BBB.

DSPE-PEG3400-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells.

DSPE-PEG2000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells.

DSPE-PEG5000-TAT is a PEG compound which composed of DSPE and a cell-penetrating peptide (TAT) (HY-P0281). DSPE-PEG5000-TAT can be used for drug delivery.

DSPE-PEG5000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells.

DSPE-PEG3400-ANG is a PEG compound which composed of DSPE and a dual-targeting ligand (Angiopep-2, ANG). ANG exhibits high LRP1 binding efficiency and has been used for glioma-targeting delivery. DSPE-PEG3400-ANG can be used for drug delivery.

DSPE-PEG2000-YIGSR is a PEG compound which composed of DSPE and a biomimetic peptide YIGSR. YIGSR interacts with the 67 kDa laminin binding protein (LBP) and promotes adhesion and spreading of a large number of cell types including endothelial cells, fibroblasts and smooth muscle cells. DSPE-PEG2000-YIGSR can be used for drug delivery.

DSPE-PEG3400-TAT is a PEG compound which composed of DSPE (HY-112530) and a cell-penetrating peptide (TAT) (HY-P0281). DSPE-PEG3400-TAT can be used for drug delivery.

DSPE-PEG2000-RVG29 is a PEG conjugate composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB), crosses the BBB, and mediates receptor-dependent transcytosis. DSPE-PEG2000-RVG29 can be used for brain-targeted drug delivery, surface modification of nanocarriers, as well as gene and nucleic acid delivery. DSPE-PEG2000-RVG29 is applicable to research related to hypoxic-ischemic brain injury, Parkinson's disease, and other conditions.

DMG-PEG2000-MG1 is a functionalized PEGylated phospholipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and an MG1 (HY-P11315) peptide as a terminal targeting/functional ligand. DMG-PEG2000-MG1 can be used in research on targeted drug delivery for neuroinflammation.

DMG-PEG2000-ANG (DMG-PEG2000-Mal-Cys-TFFYGGSRGKRNNFKTEEY) is a functionalized PEGylated phospholipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as a lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and an ANG (Angiopep-2) (HY-P2341) peptide as a terminal targeting/functional ligand. DMG-PEG2000-ANG can be used in research such as brain-targeted drug delivery.

DSG-PEG2000-ANG (DSG-PEG2000-Mal-Cys-TFFYGGSRGKRNNFKTEEY) is a functionalized PEGylated phospholipid conjugate composed of three modular components: distearoylglycerol (DSG) as a lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and an ANG (Angiopep-2) (HY-P2341) peptide as a terminal targeting/functional ligand. DSG-PEG2000-ANG can be used in research such as brain-targeted drug delivery.

DMG-PEG2000-THRPPMWSPVWP (DMG-PEG2000-Mal-Cys-THRPPMWSPVWP) is a functionalized PEGylated phospholipid conjugate composed of three modular components: 1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine (DMG) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and a TfR-T12 (THRPPMWSPVWP) (HY-P2297) peptide as a terminal targeting/functional ligand. DMG-PEG2000-THRPPMWSPVWP can be used for brain-targeted drug delivery and the construction of drug delivery systems for central nervous system diseases.

DSG-PEG2000-THRPPMWSPVWP (DSG-PEG2000-Mal-Cys-THRPPMWSPVWP) is a functionalized PEGylated phospholipid conjugate composed of three modular components: distearoylglycerol (DSG) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and a TfR-T12 (THRPPMWSPVWP) (HY-P2297) peptide as a terminal targeting/functional ligand. DSG-PEG2000-THRPPMWSPVWP can be used for brain-targeted drug delivery and the construction of drug delivery systems for central nervous system diseases.

DMG-PEG2000-LTLRWVGLMS (DMG-PEG2000-Mal-Cys-LTLRWVGLMS) is a functionalized PEGylated phospholipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and an LTLRWVGLMS peptide as a terminal targeting/functional ligand. DMG-PEG2000-LTLRWVGLMS can be used in research on targeted drug delivery for gliomas.

DSG-PEG2000-LTLRWVGLMS (DSG-PEG2000-Mal-Cys-LTLRWVGLMS) is a functionalized PEGylated phospholipid conjugate composed of three modular components: distearoylglycerol (DSG) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and an LTLRWVGLMS peptide as a terminal targeting/functional ligand. DSG-PEG2000-LTLRWVGLMS can be used in research on targeted drug delivery for gliomas.

DSG-PEG2000-MG1 is a functionalized PEGylated phospholipid conjugate composed of three modular components: distearoylglycerol (DSG) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and an MG1 (HY-P11315) peptide as a terminal targeting/functional ligand. DSG-PEG2000-MG1 can be used in research on targeted drug delivery for neuroinflammation.