Oncaspar
Based on 1 Customer Validation
Oncaspar (PEG-L-asparaginase; Pegasparaginase), a pegylated form of native Escherichia coli-derived L-asparaginase, breaks down the amino acid asparagine that are circulating in the bloodstream. Oncaspar plays an important role in acute lymphoblastic leukemia (ALL) through asparagine hydrolysis and activation of the integrated stress response (ISR) pathway.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.9%
- CAS 番号: 130167-69-0
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Oncaspar (2 IU/mL, 48 h) inhibits the cell viability of 266-6, suppresses the expression of ATF3/4 proteins, and promotes the expression of FGF21 protein[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:266-6
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Concentration:2 IU/mL
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Incubation Time:48 h
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Result:Inhibited the cell viability.
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Cell Line:266-6
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Concentration:2 IU/mL
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Incubation Time:48 h
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Result:Downregulated the expression of ATF3 proteins, upregulated the expression of FGF21 protein.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats models[2]
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Dosage:1 IU/g
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Administration:intramuscular, single dose
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Result:Increased plasma lipase levels, inhibited the weight gain of rats, increased the levels of inflammatory markers IL6 and IL1β in pancreatic tissue, caused edema and inflammatory infiltration in the pancreases of rats.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Conjugated with pegol
The product can be reconstituted/diluted with sterile PBS or saline.
化学情報
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CAS 番号 130167-69-0
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性状 Liquid
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Color Colorless to light yellow
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SMILES
[Oncaspar]
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別名
PEG-L-asparaginase; Pegasparaginase
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Young-A Heo, et al. Pegaspargase: A Review in Acute Lymphoblastic Leukaemia.Drugs. 2019 May;79(7):767-777. [Content Brief]
[2]. He J, et al., Insufficient secretion of pancreatic FGF21 is the toxicological mechanism and therapeutic target of asparaginase-associated pancreatitis. Toxicol Appl Pharmacol. 2024 Apr;485:116920. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Oncaspar 関連分類
HY-108860 関連分類
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