Peucedanin
Based on 1 Customer Validation
Peucedanin is an orally active insect growth inhibitor and coumarin compound. Peucedanin reduces Hsp27 and Hsp72 expression and blocks Ca2+ channel activity. Peucedanin induces Apoptosis and necrosis. Peucedanin reduces the relative growth rate and consumption rate of Spodoptera littoralis larvae. Peucedanin can be used in research on cervical cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 133-26-6
- 分子式: C15H14O4
- 分子量:258.27
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[2]|
HSP27 |
Hsp72 |
体外実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa B cells
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Concentration:1, 5, 10, and 15 μg/mL
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Incubation Time:5 h and 24 h
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Result:Hoechst 33342 apoptosis was 0.13% at 1 μg/mL (5 h), 0.25% at 5 μg/mL (5 h), 0.20% at 10 μg/mL (5 h), 0.60% at 15 μg/mL (5 h), 0.15% at 5 μg/mL (24 h), 0.20% at 10 μg/mL (24 h), and 1.70% at 15 μg/mL (24 h).
Annexin V apoptosis was 4.65% at 1 μg/mL (5 h), 4.80% at 5 μg/mL (5 h), 3.00% at 10 μg/mL (5 h), 8.35% at 15 μg/mL (5 h), 2.05% at 1 μg/mL (24 h), 4.80% at 5 μg/mL (24 h), 1.90% at 10 μg/mL (24 h), and 11.4% at 15 μg/mL (24 h).
PI necrosis was 0.2% at 1 μg/mL (5 h), 0.5% at 5 μg/mL (5 h), 0.6% at 10 μg/mL (5 h), 0.5% at 15 μg/mL (5 h), 0.30% at 1 μg/mL (24 h), 0.40% at 5 μg/mL (24 h), 0.90% at 10 μg/mL (24 h), and 0.90% at 15 μg/mL (24 h).
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Cell Line:HeLa B cells
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Concentration:15 μg/mL
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Incubation Time:5 h and 24 h
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Result:Hsp72 expression was inhibited by 77.5% after 24 h at 15 μg/mL.
Hsp27 was diminished by 74.0% after 5 h at 15 μg/mL compared with control.
体内実験
Peucedanin (3 μmol/g fresh wt; oral; three days) slightly decreases RGR and RCR in second-instar Spodoptera littoralis larvae[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:laboratory colony (neonate larvae)[1]
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Dosage:1.0, 2.0, 3.0, 4.0, and 5.0 μmol/g fresh wt
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Administration:oral; continuous; six days
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Result:At 1, 2, 3, 4, and 5 μmol/g fresh wt, larval growth was 68%, 23%, 22%, 18%, and 8% of control, respectively.
No larvae died during the bioassay.
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Animal Model:laboratory colony (second-instar larvae)[1]
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Dosage:3 μmol/g fresh wt
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Administration:oral; three days
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Result:At 3 μmol/g fresh wt, weight gain was 10.81 mg dry wt, diet consumed was 42.46 mg dry wt, RGR was 0.66 mg/mg/day, and RCR was 2.56 mg/mg/day.
RGR and RCR slightly decreased relative to control.
化学情報
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CAS 番号 133-26-6
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性状 Solid
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分子量 258.27
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分子式 C15H14O4
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SMILES
O=C1C=CC2=CC3=C(OC(C(C)C)=C3OC)C=C2O1
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Peucedanin 関連分類
HY-N7855 関連分類
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