Pichromene
Based on 1 Customer Validation
Pichromene (S14161) is an anticancer agent and weak PI3K inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.0%
- CAS 番号: 883046-50-2
- 分子式: C17H14FNO4
- 分子量:315.30
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保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | GI50 |
23.28 μM
Compound: 2, S14161
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Cytotoxicity against mouse B16 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against mouse B16 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
| K562 | GI50 |
1.24 μM
Compound: 2, S14161
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Cytotoxicity against human K562 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human K562 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
| LP-1 | GI50 |
0.57 μM
Compound: 2, S14161
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Cytotoxicity against human LP-1 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human LP-1 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
| MDA-MB-231 | GI50 |
8.53 μM
Compound: 2, S14161
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Cytotoxicity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
| Platelet | IC50 |
3.79 μM
Compound: S14161
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Inhibition of collagen-induced platelet aggregation in human platelet rich plasma preincubated for 10 mins followed by collagen addition by aggregometric method
Inhibition of collagen-induced platelet aggregation in human platelet rich plasma preincubated for 10 mins followed by collagen addition by aggregometric method
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[PMID: 27996269] |
| U-87MG ATCC | GI50 |
18.72 μM
Compound: 2, S14161
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Cytotoxicity against human U87 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human U87 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
化学情報
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CAS 番号 883046-50-2
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性状 Solid
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分子量 315.30
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分子式 C17H14FNO4
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Color Off-white to light yellow
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SMILES
O=[N+](C1=CC2=CC=CC(OCC)=C2OC1C3=CC=C(F)C=C3)[O-]
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別名
S14161
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
純度とドキュメンテーション
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データシート (270 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Mao X, et al. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood. 2011 Feb 10;117(6):1986-97. [Content Brief]
[2]. Fouqué A, et al. A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells. J Med Chem. 2015 Aug 27;58(16):6559-73. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Pichromene 関連分類
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