N-Methylated pomalidomide
Based on 1 Customer Validation
N-methylated pomalidomide (Pomalidomide-methyl), a derivative of Pomalidomide (HY-10984), is a cereblon (CRBN) ligand. N-methylated pomalidomide is unable to recruit CRBN that can be used as a negative control for Pomalidomide. N-methylated pomalidomide can be used to synthesize PROTAC.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.82%
- CAS 番号: 1352827-50-9
- 分子式: C14H13N3O4
- 分子量:287.27
-
保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 1352827-50-9
-
性状 Solid
-
分子量 287.27
-
分子式 C14H13N3O4
-
Color Light yellow to yellow
-
SMILES
O=C1C2=C(C(N1C3C(N(C)C(CC3)=O)=O)=O)C(N)=CC=C2
-
別名
Pomalidomide-methyl
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 100 mg/mL (348.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (274 KB)
-
SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4810 mL | 17.4052 mL | 34.8105 mL | 87.0261 mL |
| 5 mM | 0.6962 mL | 3.4810 mL | 6.9621 mL | 17.4052 mL | |
| 10 mM | 0.3481 mL | 1.7405 mL | 3.4810 mL | 8.7026 mL | |
| 15 mM | 0.2321 mL | 1.1603 mL | 2.3207 mL | 5.8017 mL | |
| 20 mM | 0.1741 mL | 0.8703 mL | 1.7405 mL | 4.3513 mL | |
| 25 mM | 0.1392 mL | 0.6962 mL | 1.3924 mL | 3.4810 mL | |
| 30 mM | 0.1160 mL | 0.5802 mL | 1.1603 mL | 2.9009 mL | |
| 40 mM | 0.0870 mL | 0.4351 mL | 0.8703 mL | 2.1757 mL | |
| 50 mM | 0.0696 mL | 0.3481 mL | 0.6962 mL | 1.7405 mL | |
| 60 mM | 0.0580 mL | 0.2901 mL | 0.5802 mL | 1.4504 mL | |
| 80 mM | 0.0435 mL | 0.2176 mL | 0.4351 mL | 1.0878 mL | |
| 100 mM | 0.0348 mL | 0.1741 mL | 0.3481 mL | 0.8703 mL |
N-Methylated pomalidomide 関連分類
HY-W586822 関連分類
Powered by Bioz