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製品番号: HY-170792

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PRMT5-IN-48

PRMT5-IN-48 (compound D3) is an orally effective PRMT5 inhibitor (IC₅₀=20.7 nM) with anticancer activity. PRMT5-IN-48 can inhibit the growth of various cancer cells, induce apoptosis (apoptosis), and arrest the cell cycle at the G0/G1 phase. PRMT5-IN-48 can be used for non-Hodgkin lymphoma (NHL) research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2640287-77-8
分子式: C₃₀H₃₇N₅O₃
分子量:515.65

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PRMT5-IN-48 構造式

CAS 番号: 2640287-77-8

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- Parmacokinetics
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

PRMT5^[1]

Histone Methyltransferase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-468	IC₅₀	7.4 nM Compound: 24	Antiproliferative activity against human MDA-MB-468 assessed as cell growth inhibition measured after 7 days by CCK-8 assay Antiproliferative activity against human MDA-MB-468 assessed as cell growth inhibition measured after 7 days by CCK-8 assay	[PMID: 37366223]
NCI-H358	IC₅₀	5 nM Compound: 24	Antiproliferative activity against human NCI-H358 assessed as cell growth inhibition measured after 7 days by CCK-8 assay Antiproliferative activity against human NCI-H358 assessed as cell growth inhibition measured after 7 days by CCK-8 assay	[PMID: 37366223]
Z-138	IC₅₀	2.2 nM Compound: 24	Antiproliferative activity against human Z138 cells assessed as cell growth inhibition measured after 7 days by CCK-8 assay Antiproliferative activity against human Z138 cells assessed as cell growth inhibition measured after 7 days by CCK-8 assay	[PMID: 37366223]

Parmacokinetics

Species	Dose	Route	Note	T_1/2	Plasma Concentration	AUC	MRT	Clearance (CL)	V_d	T_max	Bioavailability
Rat	10 mg/kg	p.o.	SD Rats	0.4 h	1366.5 ng/mL	771 ng·h/mL	0.5 h	2.5 L/h/kg	1.4 L/kg	/	/
Rat	2 mg/kg	i.v.	SD Rats	2.2 h	894 ng/mL	1028.2 ng·h/mL	1.7 h	/	/	0.1 h	26.7 %

化学情報

CAS 番号 2640287-77-8
分子量 515.65
分子式 C₃₀H₃₇N₅O₃
SMILES

O=C1C2=CC(NC3CC4(C3)CN(C4)C(C)=O)=NC=C2C5(CN1C[C@@H](CN6CCC(C=CC=C7)=C7C6)O)CC5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Li QQ, et al. Design, Synthesis, and Biological Evaluation of 3,4-Dihydroisoquinolin-1(2H)-one Derivatives as Protein Arginine Methyltransferase 5 Inhibitors for the Treatment of Non-Hodgkin's Lymphoma. J Med Chem. 2025 Jan 9;68(1):108-134. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
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PRMT5-IN-48

Histone Methyltransferase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

PRMT5-IN-48 関連分類

HY-170792 関連分類