CTLA-4
null Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4, CD152) is a founding immune checkpoint receptor of the CD28 superfamily, expressed on activated conventional T cells and constitutively on regulatory T cells (Tregs). CTLA-4 shares its ligands B7-1 (CD80) and B7-2 (CD86) with the co-stimulator CD28 but binds them with markedly higher affinity, competitively stripping B7 molecules off antigen-presenting cells and thereby terminating CD28 co-stimulation; CTLA-4 additionally delivers cell-intrinsic inhibitory signals through its cytoplasmic YVKM motif recruiting AP-2 and SHP-2, and its trans-endocytosis of B7 depletes APC co-stimulatory capacity. CTLA-4 is essential for peripheral tolerance: germline CTLA4 haploinsufficiency causes autoimmune lymphoproliferative syndrome. Ipilimumab, the first checkpoint-blocking antibody approved in cancer (melanoma), unleashes antitumor T cells by freeing B7 for CD28 engagement, with Treg depletion in tumors contributing to efficacy.
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CTLA-4 組換えタンパク質 (25)
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Inhibitors & Agonists (40)
CTLA-4 Protein, Human (HEK293, His)
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製品番号: HY-P70684
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Mouse (HEK293, Fc)
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製品番号: HY-P70706
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte Antigen 4; Cytotoxic T-Lymphocyte Protein 4; Alternative Protein CTLA4; GSE; Celiac Disease; CD; CD152 Antigen; Cytotoxic T-Lymphocyte-Associated Antigen 4; ALPS5; Insulin-Dependent Diabetes Mellitus 12; GRD4; Gluten-Sensitive Enteropathy; Cytotoxic T-Lymphocyte Associated Protein 4; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4
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CTLA-4 Protein, Mouse (HEK293, His)
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製品番号: HY-P71991
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Human (HEK293)
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製品番号: HY-P72959
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Human (Biotinylated, HEK293, mFc-Avi)
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製品番号: HY-P78890
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte Antigen 4; Cytotoxic T-Lymphocyte Protein 4; Alternative Protein CTLA4; GSE; Celiac Disease; CD; CD152 Antigen; Cytotoxic T-Lymphocyte-Associated Antigen 4; ALPS5; Insulin-Dependent Diabetes Mellitus 12; GRD4; Gluten-Sensitive Enteropathy; Cytotoxic T-Lymphocyte Associated Protein 4; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4
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CTLA-4 Protein, Human (HEK293, GST)
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製品番号: HY-P70691
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Human (HEK293, Fc)
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製品番号: HY-P70001
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Guinea pig (P.pastoris, His)
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製品番号: HY-P71986
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Rhesus Macaque (HEK293, His)
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製品番号: HY-P77345
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Canine (HEK293, His)
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製品番号: HY-P75320
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Rat (HEK293, His)
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製品番号: HY-P74215
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Rat (HEK293, Fc)
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製品番号: HY-P74216
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte Antigen 4; Cytotoxic T-Lymphocyte Protein 4; Alternative Protein CTLA4; GSE; Celiac Disease; CD; CD152 Antigen; Cytotoxic T-Lymphocyte-Associated Antigen 4; ALPS5; Insulin-Dependent Diabetes Mellitus 12; GRD4; Gluten-Sensitive Enteropathy; Cytotoxic T-Lymphocyte Associated Protein 4; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4
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CTLA-4 Protein, Human (HEK293, mFc)
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製品番号: HY-P704553
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Human (Biotinylated, HEK293, hFc-Avi)
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製品番号: HY-P72363
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Human (Biotinylated, HEK293, His-Avi)
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製品番号: HY-P78112
純度: ≥ 95%, as determined by Bis-Tris PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Mouse (Biotinylated, HEK293, His-Avi)
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製品番号: HY-P78889
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte Antigen 4; Cytotoxic T-Lymphocyte Protein 4; Alternative Protein CTLA4; GSE; Celiac Disease; CD; CD152 Antigen; Cytotoxic T-Lymphocyte-Associated Antigen 4; ALPS5; Insulin-Dependent Diabetes Mellitus 12; GRD4; Gluten-Sensitive Enteropathy; Cytotoxic T-Lymphocyte Associated Protein 4; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4
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CTLA-4 Protein, Rhesus Macaque (HEK293, Fc)
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製品番号: HY-P72958
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Mouse (Biotinylated, HEK293, His)
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製品番号: HY-P75317
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi)
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製品番号: HY-P78891
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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CTLA-4 Protein, Canine (HEK293, Fc)
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製品番号: HY-P75321
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: CTLA4; Celiac Disease 3; Prev. CELIAC3; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form; Prev. IDDM12; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; CTLA-4; Cytotoxic T-Lymphocyte-Associated Protein 4; CD152; Cytotoxic T-Lymphocyte A
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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Capetin (28-54), human
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- 分子式: Human
- 分子量: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
