Pyrantel
Based on 1 publication(s) in Google Scholar
Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 15686-83-6
- 分子式: C11H14N2S
- 分子量:206.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Pyrantel
MoreAntibiotic アイソフォーム固有の製品をすべて表示
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生物活性
Pyrantel (10 nM-10 μM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A. suum
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Concentration:10 nM-10 µM
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Incubation Time:72 h
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Result:Inhibited A. suum with a pEC50 value of 7.24.
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Cell Line:N. americanus
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Concentration:0-168.2 M (0-100 µg/mL)
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Incubation Time:72 h
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Result:Inhibited third-stage larvae and adult of N. americanus with IC50 values of 2.0 and 7.6 mg/mL, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected)[2].
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Dosage:10 mg/kg
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Administration:Oral administration; single.
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Result:Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.
化学情報
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CAS 番号 15686-83-6
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分子量 206.31
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分子式 C11H14N2S
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SMILES
CN1CCCN=C1/C=C/C2=CC=CS2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Eur J Med Chem
2024 Dec 5:279:116842. PMID: 39260319
純度とドキュメンテーション
参考文献
[1]. Martin RJ, et al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. Int J Parasitol. 2004 Aug;34(9):1083-90. [Content Brief]
[2]. Tritten L, et al. In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS Negl Trop Dis. 2011 Dec;5(12):e1457. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Pyrantel 関連分類
HY-12641A 関連分類
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