(R)-Exatecan Intermediate 1
Based on 1 Customer Validation
(R)-Exatecan Intermediate 1 is a key intermediate in the synthesis of Camptothecin (HY-16560) derivatives, and can be used to prepare Exatecan mesylate (DX8951f) (HY-13631A). (R)-Exatecan Intermediate 1 enables the synthesis of Exatecan, which exhibits low sensitivity to multidrug resistance and has great value in anti-tumor research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 110351-91-2
- 分子式: C13H13NO5
- 分子量:263.25
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保管条件:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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Camptothecins |
体外実験
(R)-Exatecan Intermediate 1 undergoes rearrangement to form intermediate B with yields of 60-79% under specified temperature and time conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 110351-91-2
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性状 Solid
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分子量 263.25
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分子式 C13H13NO5
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Color Light yellow to light brown
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SMILES
O=C1[C@@](O)(CC)C(C=C23)=C(CO1)C(N3CCC2=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (379.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[2]. Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023;13(4):950-973. [Content Brief]
[3]. Conilh L, et al. Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform. Pharmaceuticals (Basel). 2021;14(3):247. Published 2021 Mar 9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7987 mL | 18.9934 mL | 37.9867 mL | 94.9668 mL |
| 5 mM | 0.7597 mL | 3.7987 mL | 7.5973 mL | 18.9934 mL | |
| 10 mM | 0.3799 mL | 1.8993 mL | 3.7987 mL | 9.4967 mL | |
| 15 mM | 0.2532 mL | 1.2662 mL | 2.5324 mL | 6.3311 mL | |
| 20 mM | 0.1899 mL | 0.9497 mL | 1.8993 mL | 4.7483 mL | |
| 25 mM | 0.1519 mL | 0.7597 mL | 1.5195 mL | 3.7987 mL | |
| 30 mM | 0.1266 mL | 0.6331 mL | 1.2662 mL | 3.1656 mL | |
| 40 mM | 0.0950 mL | 0.4748 mL | 0.9497 mL | 2.3742 mL | |
| 50 mM | 0.0760 mL | 0.3799 mL | 0.7597 mL | 1.8993 mL | |
| 60 mM | 0.0633 mL | 0.3166 mL | 0.6331 mL | 1.5828 mL | |
| 80 mM | 0.0475 mL | 0.2374 mL | 0.4748 mL | 1.1871 mL | |
| 100 mM | 0.0380 mL | 0.1899 mL | 0.3799 mL | 0.9497 mL |
(R)-Exatecan Intermediate 1 関連分類
HY-42487B 関連分類
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