Ro 64-5229
Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. RO 64-5229 reduces the presynaptic inhibitory effect of Neuroligin 1.
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- CAS 番号: 246852-46-0
- 分子式: C17H19Cl2N3O
- 分子量:352.26
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
mGlu2[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.11 μM
Compound: 1a
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Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cells
Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cells
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[PMID: 10465539] |
| CHO | IC50 |
500 nM
Compound: 1a
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Inhibition of [3H]-DCG IV binding on rat mGluR2 transfected cell membranes from CHO cells
Inhibition of [3H]-DCG IV binding on rat mGluR2 transfected cell membranes from CHO cells
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[PMID: 10465539] |
RO 64-5229 (50 µM) reduces the presynaptic inhibitory effect of NL1 (Neuroligin 1)[1].
RO 64-5229 (0.1, 0.3, 1 µM; 20 min) inhibits the inhibitory activity of neuroligin 1 ectodomain (Ecto-NL1; mGluR2 activator) on Forskolin (Ecto-NL1 decreases the Forskolin-induced formation of cAMP) in HEK-mGluR2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK-mGluR2 cells
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Concentration:0.1, 0.3, 1 µM
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Incubation Time:20 min
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Result:Inhibited activity of Ecto-NL1( mGluR2 activator).
化学情報
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CAS 番号 246852-46-0
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分子量 352.26
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分子式 C17H19Cl2N3O
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SMILES
ClC1=C(/C(OC2CCCCCC2)=C/N3N=CN=C3)C(Cl)=CC=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
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- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Ro 64-5229 関連分類
HY-103557 関連分類
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