Rudolfomycin
Rudolfomycin is an anthracycline Antibiotic, composed of the aglycone ε-pyrromycinone and three glycosyl sugar units. Rudolfomycin inhibits the growth of mammalian tumors and exhibits antibacterial activity against Gram-positive bacteria. Rudolfomycin can be used in the research of leukemia and Gram-positive bacterial infections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 69245-38-1
- 分子式: C42H52N2O16
- 分子量:840.87
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Antibiotic アイソフォーム固有の製品をすべて表示
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生物活性
Rudolfomycin (0.25-8 μg/mL) potently inhibits the growth of gram-positive bacteria including Streptococcus pneumoniae A-9585 (MIC 0.25 μg/mL), Streptococcus pyogenes A-9604 (MIC 0.5 μg/mL), Staphylococcus aureus A-9537 (MIC 2 μg/mL), Staphylococcus aureus A-9606 (MIC 8 μg/mL), and Streptococcus faecalis A-20688 (MIC 4 μg/mL), but is inactive against gram-negative bacteria and most tested fungi[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BDF1 mice (female; implanted i.p. with 106 L-1210 leukemia ascites cells)[1]
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Dosage:12.8, 6.4, 3.2, 1.6, 0.8, 0.4 mg/kg
6.4, 3.2, 1.6, 0.8, 0.4, 0.2 mg/kg
3.2, 1.6, 0.8, 0.4, 0.2, 0.1 mg/kg
1.6, 0.8, 0.4, 0.2, 0.1, 0.05 mg/kg -
Administration:i.p.; single dose
i.p.; days 1, 4, 7
i.p.; daily, 5 days
i.p.; daily, 9 days -
Result:Attained the peak median survival time (MST) of 10.0 days and maximal % T/C value of 143 across single intraperitoneal (i.p.) bolus, intermittent day 1/4/7 i.p., 5-day daily i.p. and 9-day daily i.p. schedules at corresponding medium dose groups.
Attained a secondary MST of 9.5 days with a % T/C of 136 only in the day 1/4/7 intermittent i.p. group treated with 0.8 mg/kg.
Attained a consistent MST of 9.0 days and % T/C of 129 at multiple dosages covering all four administration modes.
Attained a uniform MST of 8.0 days and % T/C of 114 across low-dose cohorts of all four dosing regimens.
Attained a moderate MST of 7.5 days with a % T/C of 107 in the 9-day daily i.p. group at 1.6 and 0.1 mg/kg.
Attained the lowest MST of 7.0 days with a % T/C of 100 under day 1/4/7 intermittent i.p. administration at 3.2 mg/kg.
化学情報
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CAS 番号 69245-38-1
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分子量 840.87
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分子式 C42H52N2O16
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SMILES
O=C(C1[C@@](O)(CC)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4C(N)=CC([C@@H](C)O4)=O)[C@H](C)O3)[C@H](C)O2)C5=C(O)C6=C(C(C7=C(O)C=CC(O)=C7C6=O)=O)C=C15)OC
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Structure Classification
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Initial Source
Actinosporangium species ATCC 31127
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Rudolfomycin 関連分類
HY-126731 関連分類
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