SB2960
SB2960 is a receptor for activated protein C kinase 1 (RACK1) binder with a human KD of 5.65 μM. SB2960 can promote stress granule (SG) formation and exhibit potent antiviral activity across diverse viral species. SB2960 suppresses viral replication with minimal cytotoxicity by modulating host antiviral immune responses. SB2960 increases the thermal stability of RACK1 and reduces SARS-CoV-2 N protein levels. SB2960 enhances type I interferon (IFN-β) expression and inhibits RIG-I, ISG56, and RANTES expression. SB2960 can be used for the research of virus infection.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3111225-79-4
- 分子式: C34H31F3N8O3
- 分子量:656.66
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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RACK1 |
SARS-CoV-2 |
SB2960 (1.2-100 μM) induces stress granule formation in Vero cells with an EC50 of 12.31 μM and reduces SARS-CoV-2 N protein levels in a dose-dependent manner[1].
SB2960 (0.2-100 μM) demonstrates broad-spectrum antiviral activity against multiple RNA viruses in Vero, Calu-3, and Huh7 cells with IC50 values between 3.01 and 5.45 μM[1].
SB2960 (20 μM; 24 h) modulates antiviral gene expression in G3BP1-GFP U-2 OS cells treated with poly(I:C)[1].
SB2960 (0-30 μM) synergizes with Remdesivir (HY-104077) and Nirmatrelvir (HY-138687) against SARS-CoV-2 in Vero cells with high ZIP synergy scores[1].
SB2960 (0.39-700 μM; 24 h) exhibits low cytotoxicity in Vero and G3BP1-GFP U-2 OS cells with a CC50 > 100 μM[1].
SB2960 (20 μM; 24 h) increases the thermal stability of RACK1 in Vero and G3BP1-GFP U-2 OS cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero and G3BP1-GFP U-2 OS cells
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Concentration:40 μM (CETSA)
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Incubation Time:2 h (CETSA)
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Result:Increased the thermal stability of RACK1, with a higher melting temperature (Tm) compared to DMSO-treated cells.
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Cell Line:G3BP1-GFP U-2 OS cells
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Concentration:20 μM
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Incubation Time:24 h
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Result:Enhanced IFN-β expression in poly(I:C)-stimulated cells while attenuating RIG-I, ISG56, and RANTES expression.
化学情報
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CAS 番号 3111225-79-4
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分子量 656.66
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分子式 C34H31F3N8O3
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SMILES
CC1(C)OC2=CC(N3CCN(C(C4=NC=CN4C)=O)CC3)=C(NC(C5=NC=CC=C5)=O)C=C2C6=C1C=NN6C7=CC=C(C(F)(F)F)C=C7
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SB2960 関連分類
HY-181165 関連分類
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