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製品番号: HY-187472

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SMA-245

SMA-245 is an inhibitor of Filovirus glycoproteins, acting on Ebola virus (EBOV) and Marburg virus (MARV). SMA-245 blocks the endosomal membrane fusion step of filoviruses by binding to the EBOV GP1/GP2 fusion loop. SMA-245 inhibits MARV viral entry. SMA-245 can be used in research related to filovirus infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₉H₃₂N₂O₂
分子量:440.58

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SMA-245 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

EBOV

MARV

Filovirus アイソフォーム固有の製品をすべて表示 :

Cytochrome P450 アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	6.8 μM	Cytotoxicity against human A549 lung epithelial cells measured via CellTiter-Glo Luminescent Cell Viability Assay after 48 h incubation. Cytotoxicity against human A549 lung epithelial cells measured via CellTiter-Glo Luminescent Cell Viability Assay after 48 h incubation.	42475249
HeLa	CC₅₀	4.6 μM	Cytotoxicity against human HeLa cervical cancer cells measured via CellTiter-Glo Luminescent Cell Viability Assay after 48 h incubation. Cytotoxicity against human HeLa cervical cancer cells measured via CellTiter-Glo Luminescent Cell Viability Assay after 48 h incubation.	42475249

体外実験

SMA-245 (compound 41) (48 h) potently inhibits pEBOV entry in A549 cells with an EC₅₀ of 0.040 μM, also inhibits pMARV, pSUDV, and pTAFV entry, shows no activity against pBDBV, and has low activity against non-filovirus pseudoviruses^[1].
SMA-245 (40 h infection incubation; 48 h cytotoxicity incubation) potently inhibits infectious EBOV replication in HeLa cells with an EC₅₀ of 0.04 μM and infectious MARV replication with an EC₅₀ of 0.38 μM, with selectivity indices of 120 and 12, respectively^[1].
SMA-245 moderately inhibits hERG potassium channels with an IC₅₀ of 2.93 μM, representing a potential cardiac safety concern^[1].
SMA-245 has excellent plasma stability in human and mouse, high stability in human liver microsomes, moderate stability in mouse liver microsomes, and low to moderate inhibition of major CYP450 isoforms at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_last	AUC_0-∞	T_1/2	MRT_0-∞	C₀	CL	V_ss	T_max	C_max	C_min	Bioavailability
Mice^[1]	5 mg/kg	i.v.	2416 ng·h/mL	2585 ng·h/mL	6.8 h	7.1 h	1224 ng/mL	32 mL/min/kg	14 L/kg	/	/	/	/
Mice^[1]	50 mg/kg	p.o.	1637 ng·h/mL	1672 ng·h/mL	4.1 h	5.8 h	/	/	/	4.0 h	210 ng/mL	5.8 ng/mL	6.47 %

体内実験

SMA-245 (compound 41) (5-50 mg/kg; i.v., p.o.; single bolus) exhibits favorable in vivo pharmacokinetic properties following i.v. administration in male BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 440.58
分子式 C₂₉H₃₂N₂O₂
SMILES

COC1=CC2=C(C(C(CC2)C3=CC=CC=C3)C4=CC=C(C=C4)NC(C5CCNCC5)=O)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Aboukhatwa SM, et al. Configurationally Locked Ridaifen-B Analogs as Potent Ebola Virus Entry Inhibitors. Journal of medicinal chemistry. 2026 Jul 20.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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SMA-245

Filovirus アイソフォーム固有の製品をすべて表示

Cytochrome P450 アイソフォーム固有の製品をすべて表示