Stibophen

Stibophen (0-2×10^-3 M) potently inhibits PFK activity in filarial homogenates at 2 ×10^-5 M, while hamster liver PFK demonstrates roughly 1000-fold lower sensitivity^[2].
Stibophen (1.6×10^-4 M; 30 min) inhibits lactate formation in intact filarial parasites with inhibitions of ~40% in B. pahangi, D. witei, and L. carinii^[2].
Stibophen (1.6×10^-5-1.6×10^-4 M; 75 min) leads to an accumulation of hexose phosphates (G-6-P and F-6-P) and a concomitant reduction in Fructose-1,6-bisphosphate in intact filarial parasites, indicating its PFK inhibition activity^[2].
Stibophen (1.6×10^-4 M; 1 h) inhibits lactate formation from glucose and fructose-1,6-diphosphate in filarial homogenates, with aldolase reversing FDP-dependent inhibition^[2].
Stibophen (1.6×10^-5-5×10^-3 M) potently inhibits PFK and aldolase in filarial homogenates^[2].
Stibophen (1.6×10^-4 M) inhibits PFK activity in helminth homogenates but not in rat liver preparations, demonstrating its selective toxicity against parasitic enzymes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.