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Tegoprubart

(別名: AT-1501)
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Based on 1 Customer Validation

Tegoprubart (AT-1501) is a CD40 ligand inhibitor (EC50=100 ng/mL) and immunosuppressant that selectively inhibits the CD40 ligand, a co-stimulatory molecule involved in T cell activation. Tegoprubart suppresses immune rejection, prevents rejection in animal transplantation models, and reduces cell-mediated and antibody-mediated immune responses to create a more immunotolerant environment. Tegoprubart preserves renal function when combined with Mycophenolate (HY-B0421) and Corticosteroids, and maintains graft function in preclinical studies. Tegoprubart is applicable to research related to kidney transplantation and kidney transplant rejection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 99.86%
  • CAS 番号: 2628092-47-5
  • 分子量:145.56 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tegoprubart
  • Experimental Validation Results for Tegoprubart
  • Experimental Validation Results for Tegoprubart
  • Experimental Validation Results for Tegoprubart
  • Tegoprubart Chemical Structure
    Tegoprubart 構造式
CAS 番号: 2628092-47-5
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized CD40L/CD154/TRAP Protein, Human (His, HY-P72907) can bind Tegoprubart. The EC50 for this effect is 4.211 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 500 ng/mL anti-CD3 stimulated Jurkat cells(24h) with Tegoprubart (HY-P990083, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Loaded Tegoprubart on ProA biosensor, can bind CD40L/CD154/TRAP Protein, Human (HY-P7144) with an affinity constant of 4.923E-10 M as determined in BLI assay.

  • Tegoprubart Chemical Structure
    1/16
  • Tegoprubart
  • Immobilized CD40L/CD154/TRAP Protein, Human (His, HY-P72907) can bind Tegoprubart. The EC50 for this effect is 4.211 ng/mL.
  • Flow cytometric analysis of 1X106 500 ng/mL anti-CD3 stimulated Jurkat cells(24h) with Tegoprubart (HY-P990083, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Loaded Tegoprubart on ProA biosensor, can bind CD40L/CD154/TRAP Protein, Human (HY-P7144) with an affinity constant of 4.923E-10 M as determined in BLI assay.