trans-Coniferyl aldehyde
trans-Coniferyl aldehyde (compound 2) is a natural compound isolated from the buds of clove (Syzygium aromaticum).trans-Coniferyl aldehyde suppresses 63% of the UV mutable gene expression at 1.20 μM, and with an ID50 value of 0.76 μM,and has the antimutagenic activities against furylfuramide, Trp-P-1, and activated Trp-P-1.
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- CAS 番号: 20649-42-7
- 分子式: C10H10O3
- 分子量:178.18
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
容量
価格（税別）
在庫状況
数量
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
trans-Coniferyl aldehyde (compound 2) is a natural compound isolated from the buds of clove (Syzygium aromaticum).trans-Coniferyl aldehyde suppresses 63% of the UV mutable gene expression at 1.20 μM, and with an ID50 value of 0.76 μM,and has the antimutagenic
activities against furylfuramide, Trp-P-1, and activated Trp-P-1[1].
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
1.7 μM
Compound: 10
|
Growth inhibition of human A549 cells by Sulforhodamine B assay
Growth inhibition of human A549 cells by Sulforhodamine B assay
|
[PMID: 21106458] |
| A549 | IC50 |
21.18 μM
Compound: 19
|
Anticancer activity against human A549 cells by SRB assay
Anticancer activity against human A549 cells by SRB assay
|
[PMID: 21420296] |
| A549 | IC50 |
59 μM
Compound: 30
|
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
|
[PMID: 21696954] |
| B16-4A5 | IC50 |
15.3 μM
Compound: 15
|
Antimelanogenic activity in theophylline-stimulated mouse B16-4A5 cells assessed as inhibition of melanogenesis after 72 hrs relative to control
Antimelanogenic activity in theophylline-stimulated mouse B16-4A5 cells assessed as inhibition of melanogenesis after 72 hrs relative to control
|
[PMID: 27756508] |
| HeLa | GI50 |
61.8 μM
Compound: 10
|
Growth inhibition of human HeLa cells by Sulforhodamine B assay
Growth inhibition of human HeLa cells by Sulforhodamine B assay
|
[PMID: 21106458] |
| HeLa | EC50 |
9.03 μM
Compound: 5
|
Induction of cell surface translocation of MR1 in human HeLa overexpressing MR1 assessed as increase in MR1 cell surface levels incubated for 8 hrs followed by labeling with PE-conjugated anti-hMR1 antibody by flow cytometry analysis
Induction of cell surface translocation of MR1 in human HeLa overexpressing MR1 assessed as increase in MR1 cell surface levels incubated for 8 hrs followed by labeling with PE-conjugated anti-hMR1 antibody by flow cytometry analysis
|
[PMID: 37638616] |
| HT-1080 | ED50 |
4.05 μg/mL
Compound: 9
|
Cytotoxicity against human HT1080 cells after 24 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 24 hrs by MTT assay
|
[PMID: 9677271] |
| LoVo | IC50 |
23 μM
Compound: 30
|
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
|
[PMID: 21696954] |
| MCF7 | GI50 |
39.5 μM
Compound: 10
|
Growth inhibition of human MCF7 cells by Sulforhodamine B assay
Growth inhibition of human MCF7 cells by Sulforhodamine B assay
|
[PMID: 21106458] |
| PC-3 | IC50 |
35 μM
Compound: 30
|
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
|
[PMID: 21696954] |
| RAW264.7 | IC50 |
>0.3 mM
Compound: 30
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
|
[PMID: 18986199] |
| RAW264.7 | IC50 |
>0.3 μM/mL
Compound: 30
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
|
[PMID: 18986199] |
| SK-MEL-2 | IC50 |
>30 μM
Compound: 19
|
Anticancer activity against human SK-MEL-2 cells by SRB assay
Anticancer activity against human SK-MEL-2 cells by SRB assay
|
[PMID: 21420296] |
| SK-MEL-28 | IC50 |
33 μM
Compound: 30
|
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay
|
[PMID: 21696954] |
| SK-N-SH | GI50 |
10.6 μM
Compound: 10
|
Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay
Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay
|
[PMID: 21106458] |
| SK-OV-3 | IC50 |
>30 μM
Compound: 19
|
Anticancer activity against human SKOV3 cells by SRB assay
Anticancer activity against human SKOV3 cells by SRB assay
|
[PMID: 21420296] |
| U-373MG ATCC | IC50 |
28 μM
Compound: 30
|
Cytotoxicity against human U373 cells after 72 hrs by MTT assay
Cytotoxicity against human U373 cells after 72 hrs by MTT assay
|
[PMID: 21696954] |
| XF498 | IC50 |
>30 μM
Compound: 19
|
Anticancer activity against human XF498 cells by SRB assay
Anticancer activity against human XF498 cells by SRB assay
|
[PMID: 21420296] |
化学情報
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CAS 番号 20649-42-7
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分子量 178.18
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分子式 C10H10O3
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SMILES
O=C/C=C/C1=CC(OC)=C(C=C1)O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
バッチを選択:
純度:
99.98%
Assay:
99.98%
ee.:
99.98%
参考文献
Calculators
モル濃度計算機
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
=
×
×
希釈計算機
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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