TTFB
Based on 1 Customer Validation
TTFB (N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide) is a selective, non-competitive zinc-activated channel (ZAC) antagonist. TTFB inhibits Zn2+- and H+-induced ZAC currents with IC50 values of 3 μM and 8.5 μM, respectively, and has an IC50 of 4.7 μM against spontaneous activity. TTFB shows no significant agonistic, antagonistic or modulatory activity towards representative classical Cys-loop receptors including m5-HT3AR, hα3β4 nAChR, hα1β2γ2S GABAAR and hα1 GlyR. TTFB can be used to investigate the physiological and pathological functions of ZAC.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.83%
- CAS 番号: 352560-76-0
- 分子式: C14H15FN2OS
- 分子量:278.35
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
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生物活性
TTFB (0.1-100 μM; 30 seconds) potently inhibits Zn2+-evoked, H+-evoked, and spontaneous ZAC activity in Xenopus oocytes with IC50 values of 3.0 μM, 8.5 μM, and 4.7 μM, respectively, and mediates complete inhibition of Zn2+-induced responses[1].
TTFB (10 μM) mediates ZAC inhibition that is voltage-independent, as it inhibits H+-evoked currents similarly at -60 mV and +60 mV[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 352560-76-0
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性状 Solid
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分子量 278.35
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分子式 C14H15FN2OS
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SMILES
O=C(NC1=NC(=CS1)C(C)(C)C)C=2C=CC=C(F)C2
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別名
N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (267 KB)
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SDS (394 KB)
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- Français - FR (394 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TTFB 関連分類
HY-46286 関連分類
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- TTFB
- 352560-76-0
- N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide
- 5-HT Receptor
- Glycine Receptor (GlyR)
- GABA Receptor
- nAChR
- α?β?γ?S GABA? receptors
- H?
- α? glycine receptors
- Xenopus oocytes
- Zinc-Activated Channel (ZAC)
- α?β? nicotinic acetylcholine receptors
- ox-heart submitochondrial particles
- Zn2?
- 5-HT?A
- rat-heart mitochondria
- Inhibitor
- inhibitor
- inhibit