Ub4ix
Based on 1 Customer Validation
Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.32%
- CAS 番号: 2396736-46-0
- 分子式: C84H106N18O23S
- 分子量:1767.91
-
保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
化学情報
-
CAS 番号 2396736-46-0
-
性状 Solid
-
分子量 1767.91
-
分子式 C84H106N18O23S
-
Color White to off-white
-
配列
cyclo(Ac-{d-Trp}-Leu-Tyr-Leu-Asp-Asp-Ser-Gly-Asp-Trp-Trp-Ile-Cys)-Gly-NH2, cyclized via thioether
-
シーケンスの短縮
cyclo(Ac-{d-Trp}-LYLDDSGDWWIC)-G-NH2, cyclized via thioether
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 100 mg/mL (56.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (283 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Nawatha M, et al. De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains. Nat Chem. 2019 Jul;11(7):644-652. [Content Brief]
[2]. Saha A, et al. Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes. Acc Chem Res. 2023 Jul 18;56(14):1953-1965. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.5656 mL | 2.8282 mL | 5.6564 mL | 14.1410 mL |
| 5 mM | 0.1131 mL | 0.5656 mL | 1.1313 mL | 2.8282 mL | |
| 10 mM | 0.0566 mL | 0.2828 mL | 0.5656 mL | 1.4141 mL | |
| 15 mM | 0.0377 mL | 0.1885 mL | 0.3771 mL | 0.9427 mL | |
| 20 mM | 0.0283 mL | 0.1414 mL | 0.2828 mL | 0.7070 mL | |
| 25 mM | 0.0226 mL | 0.1131 mL | 0.2263 mL | 0.5656 mL | |
| 30 mM | 0.0189 mL | 0.0943 mL | 0.1885 mL | 0.4714 mL | |
| 40 mM | 0.0141 mL | 0.0707 mL | 0.1414 mL | 0.3535 mL | |
| 50 mM | 0.0113 mL | 0.0566 mL | 0.1131 mL | 0.2828 mL |
Ub4ix 関連分類
HY-P10714 関連分類
Powered by Bioz