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Cat. No.: HY-125720

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A-39183A

A-39183A is an antibiotic that shows significant cytotoxicity to HeLa cells, with an IC₅₀ value of 1.8 μM.

For research use only. We do not sell to patients.

CAS No.: 79426-51-0
Formula: C₃₄H₃₀O₁₀
Molecular Weight:598.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

A-39183A Chemical Structure

CAS No.: 79426-51-0

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

A-39183A is an antibiotic that shows significant cytotoxicity to HeLa cells, with an IC₅₀ value of 1.8 μM^[1].

All Antibiotic Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	>10 μM Compound: 2; A-39183A	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by SRB assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 32880456]
HeLa	IC₅₀	1.8 μM Compound: 2; A-39183A	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by SRB assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 32880456]
HL-60	IC₅₀	>10 μM Compound: 2; A-39183A	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32880456]
K562	IC₅₀	5.1 μM Compound: 2; A-39183A	Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32880456]

Chemical Information

CAS No. 79426-51-0
Molecular Weight 598.60
Formula C₃₄H₃₀O₁₀
SMILES

O=C1C[C@](C)(O)[C@@H](C(C)=O)C2=C1C(O)=C3C(O)=CC=CC3=C2C4=C5C=CC=C(O)C5=C(O)C6=C4[C@H](C(C)=O)[C@@](C)(O)CC6=O
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces fumigatiscleroticus
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Junxiao Wang, et al. Dimeric Tetrahydroanthracene Regioisomers and Their Monomeric Precursor Produced by Streptomyces fumigatiscleroticus HDN10255. J Nat Prod. 2020 Sep 25;83(9):2797-2802. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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A-39183A

All Antibiotic Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

A-39183A Related Classifications

HY-125720 Related Classifications