Digitoxose
Based on 1 Customer Validation
Digitoxose (D-(+)-Digitoxose) is a 2,6-dideoxy-D-ribo-hexose and the dideoxysugar moiety of Digitoxin (HY-B1357) and Digoxin (HY-B1049). Digitoxose acts by competitively inhibiting D-Glucose (HY-B0389)-stimulated Insulin (HY-P0035) release from pancreatic islets and shifting the glucose dose-response curve to the right. Digitoxose can be used in research on non-insulin-dependent diabetes mellitus.
For research use only. We do not sell to patients.
- CAS No.: 527-52-6
- Formula: C6H12O4
- Molecular Weight:148.16
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Digitoxose (22.2 mM; 1 h) does not affect glucose-stimulated oxygen consumption, but reduces cumulative insulin release from isolated islets of lean and ob/ob mice by 41% and 38%, respectively[2].
Digitoxose (5.6-27.2 mM; 1 h) competitively inhibits glucose-stimulated insulin release in isolated islets from lean and ob/ob mice, with Ki values of 16 mM and 20 mM and maximum inhibition rates of 83% and 77%, respectively[2].
Digitoxose (22.2 mM; 1 h) specifically inhibits glucose (16.7 mM)-stimulated insulin release in isolated islets from lean mice, without affecting insulin release stimulated by L-leucine (HY-N0486), L-arginine (HY-N0455), or Glibenclamide (HY-15206)[2].
Digitoxose (22.2 mM; 75 min) does not affect the oxidation of D-(U-14C)-glucose in isolated islets from lean or ob/ob mice under 16.7 mM glucose conditions[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 527-52-6
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Appearance Solid
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Molecular Weight 148.16
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Formula C6H12O4
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Color Off-white to light yellow
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SMILES
O=CC[C@H](O)[C@H](O)[C@H](O)C
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Synonyms
D-(+)-Digitoxose
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Digitoxose Related Classifications
HY-N9685 Related Classifications
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