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Cat. No.: HY-116196

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17-HETE

17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy.

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CAS No.: 128914-47-6
화학식: C₂₀H₃₂O₃
분자량:320.47

보관:

Solution, -20°C, 2 years

17-HETE Chemical Structure

CAS No.: 128914-47-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

CYP1B1

All Cytochrome P450 Isoforms :

In Vitro

17-HETE (5-20 μM) promotes the development of cardiac hypertrophy in human, through increasing CY1B1 at activity and protein levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

AC16
Concentration:

5-20 µM
Incubation Time:

24 h
Result:

Increased mRNA levels of β-MHC and ANP, increased cell surface area.

Western Blot Analysis^[1]

Cell Line:

AC16
Concentration:

20 µM
Incubation Time:

24 h
Result:

Increased expression of CYP 1B1.

In Vivo

17-HETE (1-20 μg, i.a.) stereospecificially inhibits proximal tubule ATPase activity with S- enantiomer in New Zealand white rabbit^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

New Zealand White rabbit^[2]
Dosage:

1-20 μg
Administration:

injection into artery
Result:

17S inhibited more than 70% ATPase activity at the concentration of 2 μM, while 17R enantiomer remained inactive.

Chemical Information

CAS No. 128914-47-6
Appearance Liquid
분자량 320.47
화학식 C₂₀H₃₂O₃
Color Colorless to light yellow
SMILES

CCCC(C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Solution, -20°C, 2 years

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Isse FA, et al., 17-(R/S)-hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners. Prostaglandins Other Lipid Mediat. 2023 Oct;168:106749. [Content Brief]

[2]. Carroll MA, e al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271(4 Pt 2):R863-9. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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17-HETE

All Cytochrome P450 Isoforms