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Cat. No.: HY-N18471

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5,7-Dihydroxytryptamine

(Synonyms: 5,7-DHP)

5,7-Dihydroxytryptamine (5,7-DHP) is an autofluorescent (λ_ex≈365 nm), selective neurotoxin and a transport substrate for MAO-A and 5-HT. 5,7-Dihydroxytryptamine can specifically target and damage central and peripheral 5-HTergic neurons, while affecting 5-HT-related pathways and neurotransmitter balance. 5,7-Dihydroxytryptamine can be used to establish 5-HTergic neuron injury models for studies on neural development, neurodegenerative diseases, as well as mechanisms related to platelet function and retinal neurons.

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CAS No.: 31363-74-3
화학식: C₁₀H₁₂N₂O₂
분자량:192.21

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

5,7-Dihydroxytryptamine Chemical Structure

CAS No.: 31363-74-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

MAO-A

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

All 5-HT Receptor Isoforms :

In Vitro

5,7-dihydroxytryptamine (25 μM; 60 min at 37°C) specifically labels serotonergic cells (but not dopaminergic cells) in 10-day-old primary mesencephalic cultures from 14-day-old Wistar rat foetuses^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

5,7-Dihydroxytryptamine (12.5-50.0 μg; intracerebroventricular administration; single dose) depletes norepinephrine and 5-HT in the hippocampus of mice. The depletion of norepinephrine is blocked by non-selective MAO inhibition but not by selective MAO-B inhibition^[1].
5,7-Dihydroxytryptamine (10 μg base; intracerebroventricular injection; single administration; 10 days prior to seizure induction) depletes 5-HT levels in the spinal cord of rats, but does not affect electrically induced spinal cord seizures in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 male mice (2 months old, 20-30 g)^[1]
Dosage:

12.5, 25, 50.0 μg
Administration:

intracerebroventricularly; single dose
Result:

Depleted hippocampal norepinephrine by 68% and serotonin by 71% in mice not pretreated with MAO inhibitors.

Animal Model:

Sprague-Dawley (female, 180-220 g)^[3]
Dosage:

10 µg of the base
Administration:

i.c.v.; single dose; 10 days before seizure induction
Result:

Reduced spinal cord 5-hydroxytryptamine levels to 0.21 µg/g ± 0.04; produced no changes in spinal cord norepinephrine content or electrically-induced spinal cord seizure parameters (duration of tonic flexion, tonic extension, or total seizure duration)

Chemical Information

CAS No. 31363-74-3
분자량 192.21
화학식 C₁₀H₁₂N₂O₂
SMILES

NCCC1=CNC2=C(O)C=C(O)C=C12
Synonyms

5,7-DHP
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
- Animals
rat
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Finnegan KT, et al. The amine-depleting effects of 5,7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age. Brain Res. 1989;496(1-2):251-256. [Content Brief]

[2]. Franke H, et al. 5,7-Dihydroxytryptamine--a selective marker of dopaminergic or serotonergic neurons?. Naunyn Schmiedebergs Arch Pharmacol. 2002;366(4):315-318. [Content Brief]

[3]. Jobe P C, et al. The relative significance of spinal cord norepinephrine and 5-hydroxytryptamine in electrically-induced seizure in the rat[J]. Neuropharmacology, 1978, 17(3): 185-190.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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5,7-Dihydroxytryptamine

All Monoamine Oxidase Isoforms

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

5,7-Dihydroxytryptamine Related Classifications

HY-N18471 Related Classifications